EXTL2: A Protein Involved in Intracellular Trafficking and Cell Signaling

Target Name: EXTL2

NCBI ID: G2135

EXTL2: A Protein Involved in Intracellular Trafficking and Cell Signaling

EXTL2, or Extracellular Trafficking-related Protein 2, is a protein that is expressed in various cell types and is involved in the intracellular trafficking of various proteins. It is a member of the EXT family of proteins, which are known to play a crucial role in the transport and delivery of proteins across the end membrane of cells.

EXTL2 is a 21-kDa protein that is expressed in various tissues and cells, including muscle, heart, brain, and pancreas. It is involved in the delivery of proteins to the endoplasmic reticulum (ER), which is the final destination for proteins that are synthesized in the cytoplasm.

EXTL2 functions as a scaffold protein, which helps to transport proteins to the ER by interacting with the cytoplasmic side of the protein. It does this by forming a complex with the protein transmembrane protein (TMP), which is a critical component of the endoplasmic reticulum.

EXTL2 has been shown to play a role in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism. For example, it has been shown to be involved in the regulation of T-cell receptor (TCR) signaling, which is critical for the development and function of T cells.

EXTL2 has also been shown to play a role in the regulation of cell cycle progression, which is the process by which cells divide and replicate their genetic material. It has been shown to be involved in the regulation of the G1 phase of the cell cycle, which is the stage of cell growth and preparation for cell division.

In addition to its role in cell signaling and cycle regulation, EXTL2 has also been shown to be involved in the regulation of various cellular processes that are important for the survival of cells, including stress response, DNA damage repair, and apoptosis.

Based on these findings, EXTL2 is a potential drug target or biomarker for a variety of diseases. For example, EXTL2 has been shown to be involved in the regulation of T-cell responses to cancer antigens, which could make it an attractive target for cancer therapies. Additionally, EXTL2 has been shown to play a role in the regulation of cell cycle progression, which could make it an attractive target for therapies that aim to prevent or reverse cellular senescence.

In conclusion, EXTL2 is a protein that is involved in the intracellular trafficking of various proteins and has been shown to play a role in a variety of cellular processes that are important for the survival of cells. As a result, it is a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of EXTL2 in cellular processes and its potential as a therapeutic target.

Protein Name: Exostosin Like Glycosyltransferase 2

Functions: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains

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