Study on EZHIP, A Potential Drug Target for Alzheimer's Disease

Target Name: EZHIP

NCBI ID: G340602

Study on EZHIP, A Potential Drug Target for Alzheimer's Disease

EZHIP (KIP75) is a protein that is expressed in the brain and has been shown to play a role in various neurological disorders, including Alzheimer's disease. The protein is located in the huntingtin gene family and is composed of 75 amino acid residues. It is a potential drug target (or biomarker) and is being studied for its potential therapeutic uses.

The huntingtin gene family is a family of proteins that are known for their role in the development and progression of neurodegenerative diseases. The genes encode for a protein that is involved in a variety of cellular processes, including the regulation of cell growth, differentiation, and survival. The huntingtin proteins have been implicated in the development of various neurological disorders, including Alzheimer's disease.

EZHIP is a huntingtin protein that is expressed in the brain and is involved in the regulation of various cellular processes. It is composed of 75 amino acid residues and has been shown to play a role in the development and progression of Alzheimer's disease.

Expression of EZHIP in the brain

EZHIP is expressed in the brain and is found in various neural cell types, including neurons and glial cells. It is shown to be involved in the regulation of cellular processes that are important for the survival and function of neurons, including cell growth, differentiation, and survival.

EZHIP functions as a negative regulator of the Wnt signaling pathway. The Wnt signaling pathway is a critical pathway that is involved in the regulation of cell growth and differentiation. It is a pathway that is involved in the development and maintenance of tissues and organs, including the brain.

EZHIP is shown to be involved in the regulation of the Wnt signaling pathway by blocking the activity of the transcription factor, SMAD. SMAD is a transcription factor that is involved in the regulation of gene expression and is a target

Protein Name: EZH Inhibitory Protein

Functions: Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:31086175, PubMed:31451685, PubMed:30923826). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity)

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