Target Name: CARD8
NCBI ID: G22900
Other Name(s): Caspase recruitment domain-containing protein 8, C-terminus | CARD8 variant X24 | CARD8-CT | CARD8_HUMAN | DACAR | CARD8 variant X44 | CARD-inhibitor of NF-kappa-B-activating ligand | NDPP1 | CARD8 variant X23 | CARDINAL | Caspase recruitment domain protein 8 | CARD8 variant 3 | Caspase recruitment domain-containing protein 8 (isoform j) | Caspase recruitment domain family member 8, transcript variant 2 | Caspase recruitment domain-containing protein 8 (isoform a) | KIAA0955 | CARD8 variant 2 | Apoptotic protein NDPP1 | Caspase recruitment domain-containing protein 8 (isoform b) | Caspase recruitment domain-containing protein 8 (isoform X11) | T60 | tumor up-regulated CARD-containing antagonist of CASP9 | CARD8-NT | Caspase recruitment domain family member 8, transcript variant 19 | Caspase recruitment domain family member 8, transcript variant X43 | CARD8 variant 12 | Caspase recruitment domain family member 8, transcript variant X44 | Caspase recruitment domain-containing protein 8 (isoform c) | CARD8 variant 1 | Caspase recruitment domain-containing protein 8, transcript variant X23 | DAKAR | Caspase recruitment domain family member 8, transcript variant 14 | Caspase recruitment domain family member 8,, transcript variant X24 | tumor up-regulated CARD-containing antagonist of caspase nine | Caspase recruitment domain-containing protein 8 (isoform g) | Caspase recruitment domain family member 8, transcript variant 4 | Caspase recruitment domain family member 8, transcript variant 18 | NDPP | CARD inhibitor of NF-kappaB-activating ligands | CARD8 variant 14 | Caspase recruitment domain-containing protein 8 | Caspase recruitment domain family member 8, transcript variant 12 | Caspase recruitment domain-containing protein 8 (isoform X1) | TUCAN | CARD8 variant 18 | Caspase recruitment domain-containing protein 8 isoform X6 | apoptotic protein NDPP1 | CARD8 variant 4 | Caspase recruitment domain-containing protein 8 (isoform X10) | CARD8 variant 19 | caspase recruitment domain family member 8 | Caspase recruitment domain-containing protein 8 (isoform e) | Tumor up-regulated CARD-containing antagonist of CASP9 | Caspase recruitment domain family member 8, transcript variant 1 | Caspase recruitment domain-containing protein 8, N-terminus | Tumor up-regulated CARD-containing antagonist of caspase nine | Caspase recruitment domain family, member 8, transcript variant 3

CARD8: A Potential Drug Target for Apoptosis, Adhesion and Migration

CARD8, Caspase Recruitment Domain-Containing Protein 8, is a protein that plays a crucial role in the regulation of cell death and apoptosis. It is a member of the superfamily of cysteine 鈥嬧?媝roteases, which are known for their ability to induce a range of cellular responses, including cell death and cell survival. CARD8 is widely expressed in various tissues and cells, and it has been implicated in a number of cellular processes, including cell signaling, cell adhesion, and cell survival.

One of the most significant functions of CARD8 is its role in cell apoptosis. Apoptosis is a natural process that is involved in the regulation of cell growth and survival. It is a process that is carefully controlled by a number of different factors, including the production and activation of pro-apoptotic signaling pathways. CARD8 is one of the key proteins that is involved in the regulation of apoptosis, and it is a potential drug target for the development of therapeutic strategies for a variety of diseases.

CARD8 is involved in a number of different signaling pathways that are involved in the regulation of apoptosis. One of the most significant functions of CARD8 is its role in the regulation of the production and activation of pro-apoptotic signaling pathways. For example, CARD8 has has been shown to play a role in the regulation of the production of activating transcription factor-3 (ATF-3). ATF-3 is a transcription factor that is involved in the regulation of a wide range of cellular processes, including cell survival and apoptosis. Studies have shown that CARD8 regulates the production and activity of ATF-3 by binding to ATF-3 and inhibiting its activity. This interaction between CARD8 and ATF-3 suggests that CARD8 may be a useful target for the development of therapeutic strategies for a variety of diseases, including cancer.

Another function of CARD8 is its role in the regulation of cell adhesion. CARD8 is a member of the cadherin family of transmembrane proteins, which are involved in the regulation of cell-cell adhesion. Studies have shown that CARD8 plays a role in the regulation of cadherin -based signaling pathways, which are involved in the regulation of cell adhesion. This suggests that CARD8 may be a useful target for the development of therapeutic strategies for diseases that are characterized by disrupted cell-cell adhesion, such as cancer.

In addition to its role in cell apoptosis and cell adhesion, CARD8 is also involved in the regulation of a wide range of other cellular processes. For example, CARD8 has been shown to play a role in the regulation of cell migration, and it is involved in the production of a variety of cellular signaling pathways that are involved in cell migration. This suggests that CARD8 may be a useful target for the development of therapeutic strategies for diseases that are characterized by disrupted cell migration, such as cancer.

CARD8 is widely expressed in various tissues and cells, and it is involved in a wide range of cellular processes. Its role in the regulation of cell apoptosis, cell adhesion, and cell migration suggests that it may be a useful target for the development of therapeutic strategies for a variety of diseases. As a result, CARD8 is a potential drug target for the development of therapeutic strategies for a wide range of diseases.

Protein Name: Caspase Recruitment Domain Family Member 8

Functions: Inflammasome sensor, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis of CD4(+) T-cells and macrophages (PubMed:11821383, PubMed:11408476, PubMed:15030775, PubMed:32840892, PubMed:32051255, PubMed:33542150, PubMed:34019797, PubMed:36357533). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:11821383, PubMed:11408476, PubMed:15030775, PubMed:36357533). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as HIV-1 protease activity or Val-boroPro inhibitor, and mediates CARD8 inflammasome activation (PubMed:32840892, PubMed:33542150, PubMed:36357533). In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the CARD8 inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:33053349, PubMed:32840892, PubMed:32051255, PubMed:33542150, PubMed:36357533). Ability to sense HIV-1 protease activity leads to the clearance of latent HIV-1 in patient CD4(+) T-cells after viral reactivation; in contrast, HIV-1 can evade CARD8-sensing when its protease remains inactive in infected cells prior to viral budding (PubMed:33542150). Also acts as a negative regulator of the NLRP3 inflammasome (PubMed:24517500). May also act as an inhibitor of NF-kappa-B activation (PubMed:11551959, PubMed:12067710)

More Common Targets

CARD8-AS1 | CARD9 | Cardiac Troponin | CARF | CARHSP1 | CARM1 | CARMAL | CARMIL1 | CARMIL2 | CARMIL3 | CARMN | Carnitine O-Palmitoyltransferase (CPT) | Carnitine O-Palmitoyltransferase 1 (CPT-1) | Carnitine O-palmitoyltransferase 2 | CARNMT1 | CARNS1 | CARS1 | CARS1-AS1 | CARS2 | CARTPT | CASC11 | CASC15 | CASC16 | CASC17 | CASC18 | CASC19 | CASC2 | CASC20 | CASC21 | CASC22 | CASC3 | CASC6 | CASC8 | CASC9 | CASD1 | Casein Kinase | Casein kinase I | Casein Kinase I gamma | Casein kinase II (CKII) | CASK | CASKIN1 | CASKIN2 | CASKP1 | CASP1 | CASP10 | CASP12 | CASP14 | CASP16P | CASP1P2 | CASP2 | CASP3 | CASP4 | CASP4LP | CASP5 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | Caspase | CASQ1 | CASQ2 | CASR | CASS4 | CAST | CASTOR1 | CASTOR2 | CASTOR3P | CASZ1 | CAT | Cathepsin | CATIP | CATIP-AS1 | CATSPER1 | CATSPER2 | CATSPER2P1 | CATSPER3 | CATSPER4 | CATSPERB | CATSPERD | CATSPERE | CATSPERG | CATSPERZ | CAV1 | CAV2 | CAV3 | CAVIN1 | CAVIN2 | CAVIN3 | CAVIN4 | CBARP | CBFA2T2 | CBFA2T3 | CBFA2T3-ZNF651 corepressor complex | CBFB | CBL | CBLB | CBLC | CBLIF | CBLL1