Understanding CADM1: Potential Drug Target for Cell-Cell Adhesion and Signaling

Target Name: CADM1

NCBI ID: G23705

Understanding CADM1: Potential Drug Target for Cell-Cell Adhesion and Signaling

CADM1, also known as cell adhesion molecule 1 (isoform A), is a protein that plays a crucial role in cell-cell adhesion. It is a transmembrane protein that is expressed in a variety of tissues and cells, including epithelial, mesenchymal, and neural cells. CADM1 is involved in many different cellular processes, including cell signaling, migration, and the formation of tissues and organs.

One of the key functions of CADM1 is its role in cell-cell adhesion. This involves the formation of tight junctions, which are specialized junctions that form when two cells come into close contact. tight junctions help to maintain the integrity of the cell membrane and prevent cells from coming into contact with each other, which can cause problems such as cancer.

Another important function of CADM1 is its role in cell signaling. CADM1 is involved in many signaling pathways that regulate cell behavior, including the Wnt signaling pathway. This pathway is important for many different functions in development and growth, including the formation of tissues and organs.

CADM1 is also involved in many different cellular processes that are important for normal development and growth. For example, it is involved in the development and maintenance of the nervous system, and it is involved in the formation of the placenta.

In addition to its role in cell signaling and adhesion, CADM1 is also involved in many different cellular processes that are important for normal function. For example, it is involved in the production of many different proteins that are involved in the cell signaling pathway. It is also involved in the regulation of cell growth and the formation of tissues and organs.

Given the many different functions of CADM1, it is not surprising that it has been identified as a potential drug target. Many researchers are studying CADM1 to see if it can be used to treat a variety of different conditions, including cancer, neurodegenerative diseases, and developmental disorders.

One of the challenges in studying CADM1 as a drug target is its complex structure. CADM1 is a transmembrane protein that is involved in many different cellular processes, which makes it difficult to understand exactly how it works. In order to study CADM1 as a drug target, researchers have had to use a variety of techniques, including cell-based assays, biochemical assays, and computer simulations.

Another challenge in studying CADM1 as a drug target is its role in many different cellular processes. As mentioned earlier, CADM1 is involved in many different cellular processes that are important for normal development and growth. This makes it difficult to understand exactly how it works and how it can be used to treat a variety of different conditions.

Despite these challenges, researchers are making progress in studying CADM1 as a drug target. Many researchers are using cell-based assays to study the effects of different drugs on CADM1 expression and function. They are also using biochemical assays to study the effects of different drugs on the formation of tight junctions and other cellular processes.

In addition to these studies, researchers are also using computer simulations to study the structure and function of CADM1. This has helped them to understand how the protein works at the molecular level and has given them insights into its potential targets.

Overall, CADM1 is a protein that plays a crucial role in many different cellular processes. Its involvement in cell-cell adhesion, signaling, and development makes it an attractive target for drug research. While there are still many challenges to be overcome, researchers are making progress in studying its potential as a drug.

Protein Name: Cell Adhesion Molecule 1

Functions: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:22438059, PubMed:12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246)

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