CALHM3: A Potential Drug Target and Biomarker (G119395)

Target Name: CALHM3

NCBI ID: G119395

CALHM3: A Potential Drug Target and Biomarker

Calcium-dependent homeostasis (Ca2+ homeostasis) is a critical regulator of various physiological processes in the body, including muscle contractions, nerve function, and brain activity. The third gene in the Ca2+-dependent homeostasis gene family, known as CALHM3, has recently been identified as a potential drug target and biomarker.

The Ca2+-dependent homeostasis gene family consists of four genes: CALHM1, CALHM2, CALHM3, and CALHM4. These genes encode for different proteins that are involved in the regulation of Ca2+ levels in the body. The most well-studied gene is CALHM1, also known as TRPV1, which encodes the TRPV1 receptor, which is involved in the sensation of pain and temperature. The other three genes, CALHM2, CALHM3, and CALHM4, encode for proteins that are involved in the regulation of Ca2+ homeostasis.

Recent studies have shown that the Ca2+-dependent homeostasis gene family plays a crucial role in the regulation of various physiological processes in the body. For example, studies have shown that the Ca2+ homeostasis gene family is involved in the regulation of muscle contractions, nerve function, and brain activity. Additionally, the Ca2+ homeostasis gene family is also involved in the regulation of inflammation and immune responses.

One of the most promising aspects of the Ca2+ homeostasis gene family is its potential as a drug target. The Ca2+-dependent homeostasis gene family has been shown to play a role in the regulation of various physiological processes in the body, including muscle contractions, nerve function, and brain activity. This suggests that the Ca2+ homeostasis gene family may be a useful target for the development of new drugs for a variety of diseases.

In addition to its potential as a drug target, the Ca2+ homeostasis gene family has also been shown to be a potential biomarker for various diseases. The Ca2+ homeostasis gene family is involved in the regulation of various physiological processes in the body, including muscle contractions, nerve function, and brain activity. This suggests that the Ca2+ homeostasis gene family may be a useful biomarker for the diagnosis and treatment of various diseases.

The Ca2+-dependent homeostasis gene family has been shown to play a role in the regulation of various physiological processes in the body. The most well-studied gene is CALHM1, also known as TRPV1, which encodes the TRPV1 receptor. The other three genes, CALHM2, CALHM3, and CALHM4, encode for proteins that are involved in the regulation of Ca2+ homeostasis. The Ca2+ homeostasis gene family is involved in the regulation of various physiological processes in the body, including muscle contractions, nerve function, and brain activity. Additionally, the Ca2+ homeostasis gene family is also involved in the regulation of inflammation and immune responses.

Recent studies have shown that the Ca2+ homeostasis gene family plays a crucial role in the regulation of various physiological processes in the body. For example, studies have shown that the Ca2+ homeostasis gene family is involved in the regulation of muscle contractions, nerve function, and brain activity. Additionally, the Ca2+ homeostasis gene family is also involved in the regulation of inflammation and immune responses.

In conclusion, the Ca2+-dependent homeostasis gene family, specifically the gene encoding for the protein CALHM3, has the potential to be a drug target and biomarker for various diseases. Further research is needed to understand the full role of the Ca2+ homeostasis gene family in the regulation of physiological processes in the body.

Protein Name: Calcium Homeostasis Modulator 3

Functions: Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances

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