CARD14: A Potential Drug Target for Cardiovascular Diseases (G79092)

Target Name: CARD14

NCBI ID: G79092

CARD14: A Potential Drug Target for Cardiovascular Diseases

CARD14 (Carma 2) is a protein that is expressed in the heart and is known for its role in cardiac function. It is a member of the superfamily of transmembrane protein (SMP) and is composed of four transmembrane segments and a cytoplasmic tail. CARD14 is a potential drug target in the field of cardiovascular diseases due to its involvement in various cardiac functions.

CARD14 is a critical protein for cardiac development and has been implicated in the regulation of various cardiac functions such as contractility, pacemaker activity, and cardiac rhythm. It is a key regulator of cardiac muscle contractions and has been shown to play a role in the regulation of heart rate and cardiac output. CARD14 is also involved in the regulation of ion channels, which are critical for the flow of electrical signals through the heart.

One of the most significant findings related to CARD14 is its role in the regulation of heart failure. Heart failure is a condition in which the heart is not able to pump enough blood to meet the body's needs, which can lead to symptoms such as fatigue, shortness of breath, and dizziness. Studies have shown that CARD14 plays a critical role in the regulation of heart failure by maintaining the proper functioning of heart muscle cells.

Another area of 鈥嬧?媟esearch related to CARD14 is its role in the regulation of hypertension. Hypertension, or high blood pressure, is a common condition that can lead to various cardiovascular problems, including heart failure. Studies have shown that CARD14 plays a critical role in the regulation of hypertension by controlling the diameter of blood vessels.

CARD14 is also involved in the regulation of inflammation in the body. Inflammation is a natural response of the immune system to injury or infection, but chronic inflammation can lead to various cardiovascular problems. Studies have shown that CARD14 plays a critical role in the regulation of inflammation by controlling the production of pro-inflammatory molecules.

CARD14 is also involved in the regulation of cellular processes in the heart, such as cell signaling and signaling pathways. Studies have shown that CARD14 plays a critical role in the regulation of cellular processes in the heart by controlling the formation of new blood vessels and the growth of heart muscle cells.

In conclusion, CARD14 is a protein that is expressed in the heart and is involved in various cellular processes that are critical for cardiac function. It is a potential drug target in the field of cardiovascular diseases due to its involvement in the regulation of various cardiac functions. . Further research is needed to fully understand the role of CARD14 in the regulation of cardiac function and to develop effective treatments for cardiovascular diseases.

Protein Name: Caspase Recruitment Domain Family Member 14

Functions: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis

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