COG4: A Potential Drug Target for Cancer (G25839)

Target Name: COG4

NCBI ID: G25839

COG4: A Potential Drug Target for Cancer

COG4, a protein complex involved in the regulation of cell growth and differentiation, has been identified as a potential drug target or biomarker in the field of cancer. The protein is composed of four subunits: COG4A, COG4B, COG4C, and COG4D.1. COG4A, COG4B, and COG4D are expressed in most tissues and cells, while COG4C is exclusive to the brain.2

COG4 is involved in the regulation of various cellular processes, including cell growth, differentiation, and cell-cell adhesion. It plays a critical role in the development and maintenance of tissues and organs, as well as in the regulation of tissue homeostasis.3

One of the key functions of COG4 is its role in cell-cell adhesion. COG4 helps to regulate the assembly and disassembly of tight junctions, which are a type of cell-cell adhesion structure.4 tight junctions are essential for maintaining tissue architecture and have been implicated in various diseases, including cancer.5

COG4 is also involved in the regulation of cell growth and differentiation. It has been shown to play a role in the regulation of cell proliferation and the expression of various cell surface genes.6

COG4 has also been shown to be involved in the regulation of cell death. It has been shown to play a role in the regulation of apoptosis, which is a normal form of cell death that helps to remove damaged or dysfunctional cells from the body.7

COG4 has been shown to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function and the production of pro-inflammatory cytokines.8

COG4 has also been shown to be involved in the regulation of pain perception. It has been shown to play a role in the regulation of pain modulation and the production of pro-inflammatory cytokines.9

In conclusion, COG4 is a protein complex that is involved in a variety of cellular processes that are important for tissue development and homeostasis. Its role in cell-cell adhesion, cell growth and differentiation, apoptosis, inflammation, and pain perception makes it a potential drug target or biomarker. Further research is needed to fully understand the role of COG4 in these processes and to develop effective therapies for the treatment of cancer and other diseases.

Protein Name: Component Of Oligomeric Golgi Complex 4

Functions: Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132)

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