The Potential Drug Target or Biomarker: ARFIP1 (ADP Ribosylation Factor Interacting Protein 1)

Target Name: ARFIP1

NCBI ID: G27236

The Potential Drug Target or Biomarker: ARFIP1 (ADP Ribosylation Factor Interacting Protein 1)

ARFIP1 (ADP Ribosylation Factor Interacting Protein 1) is a protein that plays a critical role in various cellular processes, including cell signaling, DNA replication, and protein synthesis. It is a key regulator of the RNA polymerase II (RPNI) complex, which is responsible for synthesizing proteins from RNA in the cytosol. RPNI is a protein that uses ADP ribosylation to add a phosphate group to specific amino acids, which is necessary for protein synthesis.

ARFIP1 is a 22-kDa protein that is expressed in various cell types. It is composed of 155 amino acids and has a calculated pI of 11.9. ARFIP1 is predominantly localized to the cytosol, and its concentration in the cytosol is 14% of total cell protein. It has a predicted localization in the nucleus, where it is associated with the RPNI complex.

ARFIP1 is a protein that has been identified as a potential drug target or biomarker. Its unique structure and subcellular localization make it an attractive target for small molecules. In addition, its involvement in various cellular processes makes it an attractive candidate for drug development.

Drug Target Potential

ARFIP1 is a protein that is involved in various cellular signaling pathways. It is a key regulator of the RPNI complex, which is responsible for synthesizing proteins from RNA in the cytosol. The RPNI complex is a protein that uses ADP ribosylation to add a phosphate group to specific amino acids, which is necessary for protein synthesis.

ARFIP1 is a protein that has been shown to play a critical role in the regulation of gene expression. It is a transcription factor that can interact with DNA to regulate gene transcription. It has been shown to interact with various DNA-binding proteins, including DNMTAT, MLL1, and HDACs.

ARFIP1 is also a protein that is involved in the regulation of cellular processes such as cell signaling, DNA replication, and protein synthesis. It is a key regulator of the G1/S transition, which is a critical step in the cell cycle. It is also involved in the regulation of DNA replication and protein synthesis.

Biomarker Potential

ARFIP1 is a protein that has been shown to play a critical role in the regulation of cancer progression. It is a transcription factor that can interact with DNA to regulate gene transcription. It has been shown to be involved in the regulation of various cancer-related processes, including cell cycle progression, apoptosis, and angiogenesis.

ARFIP1 is also a protein that has been shown to play a critical role in the regulation of inflammation. It is involved in the regulation of various inflammatory processes, including the regulation of cytokine production and the modulation of immune cell function.

Conclusion

In conclusion, ARFIP1 is a protein that has been identified as a potential drug target or biomarker. Its unique structure and subcellular localization make it an attractive target for small molecules. Its involvement in various cellular signaling pathways and processes makes it an attractive candidate for drug development. Further research is needed to fully understand the potential of ARFIP1 as a drug target or biomarker.

Protein Name: ADP Ribosylation Factor Interacting Protein 1

Functions: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988)

More Common Targets