ARHGEF16: A Potential Drug Target and Biomarker (G27237)

Target Name: ARHGEF16

NCBI ID: G27237

ARHGEF16: A Potential Drug Target and Biomarker

ARHGEF16 (Otthump00000000684) is a protein that is expressed in various tissues throughout the body. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling.

The GPCR family includes many different subfamilies, among which ARHGEF16 belongs to the ARG/GPCR subfamily. Members of this subfamily are expressed in different tissues and organs and play important roles in many biological processes.

ARHGEF16 is a 7kDa protein whose encoding gene is located on the 14th pair of human chromosomes. It is expressed in a variety of tissues and organs, including lung, spleen, liver, heart, kidney, uterus, and brain.

ARHGEF16 plays an important role in many biological processes, especially in the nervous system and endocrine system. It is associated with multiple neurotransmitter receptors, including dopamine and norepinephrine receptors, as well as thyroid hormone receptors.

ARHGEF16 is also associated with many important metabolic processes, including glucose and fatty acid metabolism. It is related to multiple enzymes in glucose and fatty acid metabolism, including glucose transporters and fatty acid transporters.

In drug development, ARHGEF16 is considered a potential drug target because it is related to a variety of important biological processes. Some studies have shown that ARHGEF16 can be a target for new drugs to treat neurological and metabolic diseases.

In addition, ARHGEF16 can also be used as a potential biomarker to detect disease progression and treatment efficacy. For example, the expression level of ARHGEF16 can be used to assess the severity and effectiveness of treatment in Parkinson's disease, as well as to assess glycemic control in patients with diabetes.

In summary, ARHGEF16 is an important protein related to a variety of important biological processes. It is a potential target in drug development and disease diagnosis. Future studies will further reveal the role of ARHGEF16 in biology and provide more evidence for its application as a drug target or biomarker.

Protein Name: Rho Guanine Nucleotide Exchange Factor 16

Functions: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6

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