ARNT: A Protein Regulator of Neural Tube Development and Immune System

Target Name: ARNT

NCBI ID: G405

ARNT: A Protein Regulator of Neural Tube Development and Immune System

ARNT (ARNT-HUMAN) is a protein that is expressed in the human placenta, and it has been shown to play a role in the development and maintenance of pregnancy. The ARNT protein is a key regulator of the neural tube, which forms the baby's brain and spinal cord.

Research has also suggested that ARNT may be a drug target or biomarker for various diseases, including cancer, neurodegenerative disorders, and reproductive system disorders.

One of the main functions of ARNT is to regulate the number of neural tube migrates, which are the cells that form the baby's neural network. During development, these migrates are important for the formation of the baby's brain and spinal cord, and any abnormalities in the number or pattern of these migrates can lead to a variety of disorders, including Down syndrome and spinal muscular atrophy.

In addition to its role in neural tube development, ARNT has also been shown to play a role in the regulation of stem cells. These cells have the ability to give rise to all of the different cell types of the body, and their proper functioning is essential for the development and maintenance of tissues and organs.

ARNT has also been shown to be involved in the regulation of the immune system. These proteins help to keep the immune system in check, preventing it from attacking healthy cells and tissues. This is important for preventing the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.

In addition to its functions in neural tube development and immune system regulation, ARNT has also been shown to be involved in the regulation of cell signaling pathways. These are the processes by which cells communicate with one another, and they are important for the development and maintenance of tissues and organs.

The potential uses of ARNT as a drug target or biomarker are vast and varied. In addition to its role in the treatment of cancer and neurodegenerative disorders, ARNT has also been shown to be a potential target for therapies aimed at preventing or treating autoimmune diseases.

In addition to its potential clinical applications, ARNT is also of interest to researchers because of its unique structure and biology. These characteristics make it an ideal candidate for study as a potential drug target or biomarker.

Overall, ARNT is a protein that has the potential to revolutionize our understanding of the biology of pregnancy and the development of various diseases. Further research is needed to fully understand its role and potential uses.

Protein Name: Aryl Hydrocarbon Receptor Nuclear Translocator

Functions: Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409)

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