Unlocking the Potential of ASCC2: A novel Drug Target and Biomarker

Target Name: ASCC2

NCBI ID: G84164

Unlocking the Potential of ASCC2: A novel Drug Target and Biomarker

Signal cointegration is a crucial process in various biological systems, including cell signaling pathways. The complex subunit 2 (isoform 1) of the Activating Signal Cointegrator 2 (ASCC2) gene has been identified as a potential drug target and biomarker. In this article, we will explore the ASCC2 gene, its function, and its potential as a drug target.

History of ASCC2

ASCC2, also known as cointegrator-associated protein 2, is a non-protein protein that plays a critical role in the intracellular signaling pathway known as the Ser/Thr signaling pathway. This pathway is involved in various cellular processes, including cell growth, differentiation, and survival. The ASCC2 gene has been identified in various organisms, including humans.

Function of ASCC2

The ASCC2 gene encodes a protein that is composed of two distinct domains: a N-terminal transmembrane domain and a C-terminal non-membrane domain. The N-terminal domain contains a putative N-terminal hypervariable region (HVR) that is involved in protein-protein interactions and may be involved in the regulation of ASCC2 function. The C-terminal domain encodes a protein that contains a unique juxtamodulin-like domain (JMD) and is involved in protein-protein interactions, including a conserved N-terminal hypervariable region (HVR) that is similar to the N-terminal domain in ASCC2.

ASCC2 is involved in the regulation of various cellular processes, including cell signaling pathways, cell growth, and apoptosis. Studies have shown that ASCC2 plays a critical role in the regulation of cell proliferation and survival. ASCC2 has also been shown to be involved in the regulation of cell migration and the maintenance of tissue structure.

Potential Drug Target

The ASCC2 gene has been identified as a potential drug target due to its involvement in various cellular processes that are crucial for human health and disease. One of the potential drug targets for ASCC2 is the regulation of cell proliferation and survival.

Drugs that target ASCC2 have the potential to inhibit its function in the regulation of cell proliferation and survival, leading to the inhibition of cellular processes that are associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

ASCC2 as a Biomarker

ASCC2 has also been identified as a potential biomarker for various diseases. The regulation of ASCC2 function is implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Studies have shown that changes in ASCC2 function are associated with the development of various diseases, including cancer and neurodegenerative diseases. For example, ASCC2 has been shown to be involved in the regulation of neurogenesis and the development of neurodegenerative diseases, including Alzheimer's disease.

Conclusion

In conclusion, the ASCC2 gene has been identified as a potential drug target and biomarker. Its function in the regulation of cell signaling pathways and its involvement in various diseases make it an attractive target for drug development. Further research is needed to fully understand the function of ASCC2 and its potential as a drug target and biomarker.

Protein Name: Activating Signal Cointegrator 1 Complex Subunit 2

Functions: Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016). As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes (By similarity)

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