ASPN: A Drug Target / Disease Biomarker (G54829)

Target Name: ASPN

NCBI ID: G54829

ASPN: A Drug Target / Disease Biomarker

ASPN, or aspartate aminotransferase protein, is a protein that is expressed in various tissues throughout the body. It is a key enzyme that is involved in the metabolism of proteins, and it has been identified as a potential drug target and biomarker for various diseases.

ASPN is a cytoplasmic protein that is primarily located in the endoplasmic reticulum (ER) and is also expressed in the cytoplasm. It is a member of the aspartate aminotransferase (ASAT) family and is responsible for the transfer of aspartate groups from the amino acids that are being synthesized to the amino acids that are being degraded. This process is essential for the proper function of proteins and is a key step in the regulation of protein homeostasis.

ASPN has been shown to play a role in the regulation of cellular processes that are important for the development and progression of various diseases. For example, ASPN has been shown to be involved in the regulation of cell signaling pathways that are involved in the development of cancer. In addition, ASPN has also been shown to be involved in the regulation of the immune response and has been implicated in the development of autoimmune diseases.

ASPN has also been identified as a potential drug target for the treatment of various diseases. For example, ASPN has been shown to be involved in the regulation of the production of cancer cells and has been shown to inhibit the growth of cancer cells in cell culture. In addition, ASPN has also been shown to play a role in the regulation of the production of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

ASPN is also a potential biomarker for the diagnosis and prognosis of various diseases. For example, ASPN has been shown to be involved in the regulation of the production of certain proteins that are involved in the development of Alzheimer's disease, and has been used as a biomarker for the diagnosis of this disease. In addition, ASPN has also been shown to be involved in the regulation of the production of other proteins that are involved in the development of Parkinson's disease, and has been used as a biomarker for the diagnosis of this disease.

In conclusion, ASPN is a protein that is expressed in various tissues throughout the body and is involved in the metabolism of proteins. It has been identified as a potential drug target and biomarker for various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. Further research is needed to fully understand the role of ASPN in these processes and to develop effective treatments for these diseases.

Protein Name: Asporin

Functions: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity

More Common Targets