ATP10A: Key Enzyme in Cellular Signaling and Energy Metabolism

Target Name: ATP10A

NCBI ID: G57194

ATP10A: Key Enzyme in Cellular Signaling and Energy Metabolism

ATP10A, also known as phospholipid-transporting ATPase VA, is a protein that plays a crucial role in cellular signaling and energy metabolism. It is a key enzyme in the transport of phospholipids across cell membranes, which are the boundaries between cells and the surrounding environment . This process is essential for maintaining the structural integrity of the cell membrane and for the delivery of nutrients and waste products.

ATP10A is a member of the ATPase family, which is a group of proteins that use ATP as an energy source to perform various cellular functions. The ATPase family is characterized by the presence of a catalytic active site, a transmembrane segment, and a cytoplasmic tail . This protein is found in various cell types, including bacteria, archaea, and eukaryotes.

ATP10A is a 120-kDa protein that is expressed in most tissues and cells. It is primarily localized to the endoplasmic reticulum (ER), which is the primary protein synthesis and delivery system in eukaryotic cells. The ER is a specialized organ that forms the boundary between the cytoplasm and the nucleus. The ER contains a variety of enzymes that are involved in protein synthesis, folding, and transport.

ATP10A is involved in the transport of phospholipids across the ER membrane. Phospholipids are a type of lipid molecule that are crucial for cellular signaling and energy metabolism. They include lipoproteins, which are the major components of cell membranes, as well as phospholipid esters, which are modified versions of phospholipids that play important roles in cellular signaling.

ATP10A is a key enzyme in the transport of these molecules across the ER membrane. It uses ATP to pump phospholipids across the membrane from the cytoplasm to the ER. This process is essential for maintaining the structural integrity of the cell membrane and for the delivery of nutrients and waste products.

ATP10A is also involved in the regulation of various cellular processes. For example, it is involved in the uptake of nutrients into the cell by vesicles that form the endoplasmic reticulum. It also plays a role in the export of waste products, such as phosphatidylcholine, which is a major component of cell membranes.

In addition to its role in cellular signaling and energy metabolism, ATP10A is also a potential drug target. Several studies have identified potential drug-concepts for ATP10A, including inhibitors of ATP10A-mediated protein synthesis, modulators of ATP10A activity, and compounds that can modulate the expression of ATP10A. These compounds have the potential to treat a variety of diseases, including heart disease, cancer, and neurodegenerative diseases.

In conclusion, ATP10A is a protein that plays a crucial role in cellular signaling and energy metabolism. It is involved in the transport of phospholipids across the ER membrane and is a key enzyme in the regulation of various cellular processes. Its potential as a drug target makes it an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of ATP10A in cellular signaling and to develop effective treatments.

Protein Name: ATPase Phospholipid Transporting 10A (putative)

Functions: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492)

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