ATP13A1: A Key Regulator of Ion Channels and Neurodegenerative Diseases

Target Name: ATP13A1

NCBI ID: G57130

ATP13A1: A Key Regulator of Ion Channels and Neurodegenerative Diseases

ATP13A1 (KIAA1825) is a protein that is expressed in various tissues of the body, including the brain, heart, and skeletal muscles. It is a key regulator of the ion channels that are responsible for the rapid and efficient transport of ions through the cell membrane. In addition to its role in cell signaling, ATP13A1 has also been shown to play a key role in the regulation of muscle contractions and the development of neurodegenerative diseases.

The Importance of Ion Channels
Ion channels are critical to the function of most cells in the body. They allow the free flow of ions, such as calcium and potassium, into and out of the cell, which is essential for maintaining the proper balance of these ions in the cell's interior . When ions are transported into the cell, they can trigger a variety of downstream signaling pathways that are important for cell signaling and survival. Similarly, when ions are transported out of the cell, they can play a role in the regulation of ion balance and the maintenance of the extracellular environment.

ATP13A1: A Key Regulator of Ion Channels
ATP13A1 is a protein that is expressed in a variety of tissues and is involved in the regulation of ion channels. It is a key regulator of the potassium channels, which are responsible for the rapid and efficient transport of potassium ions into and out of the cell . In addition to its role in potassium channels, ATP13A1 is also involved in the regulation of other ion channels, including the sodium channels that are responsible for the rapid and efficient transport of sodium ions into and out of the cell.

ATP13A1 is shown to play a key role in the regulation of muscle contractions and the development of neurodegenerative diseases. It is expressed in the muscle fibers and is involved in the regulation of the contraction and relaxation of muscle cells. In addition, ATP13A1 is also shown to play a key role in the regulation of the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Targeting ATP13A1
ATP13A1 is a protein that is being targeted by researchers as a potential drug target for a variety of neurodegenerative diseases. Studies have shown that blocking the activity of ATP13A1 has the potential to treat a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

Conclusion
In conclusion, ATP13A1 is a protein that is expressed in various tissues and is involved in the regulation of ion channels. It is a key regulator of the potassium and sodium channels and is being targeted by researchers as a potential drug target for a variety of neurodegenerative diseases. Further research is needed to fully understand the role of ATP13A1 in cell signaling and the development of neurodegenerative diseases.

Protein Name: ATPase 13A1

Functions: Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005)

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