ATF4P4: A Drug Target / Disease Biomarker (G100127952)

Target Name: ATF4P4

NCBI ID: G100127952

Other Name(s): ATF4B | activating transcription factor 4 pseudogene 4 | Activating transcription factor 4 pseudogene 4

ATF4P4: A Drug Target / Disease Biomarker

ATF4P4, also known as heat shock protein 4.2 (Hsp4.2), is a protein that is expressed in various tissues and cells, including the brain, heart, and muscle. It is a member of the Hsp family of proteins, which are known for their ability to withstand and recover from thermal stress, such as high temperatures or overexertion.

ATF4P4 has been shown to play a role in a variety of cellular processes, including the regulation of protein synthesis and turnover, DNA replication and repair, and cell survival. It has also been shown to be involved in the development and progression of a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease.

One of the key features of ATF4P4 is its ability to form a complex with other proteins, including the transcription factor p21 (TGF-β1). This complex is known as the p21-ATF4-p21 complex and is involved in the regulation of cell growth, apoptosis, and translation of gene expression.

In addition to its role in the p21-ATF4-p21 complex, ATF4P4 has also been shown to play a role in the regulation of the DNA damage response (DDR), a critical process that helps cells respond to DNA damage and ensure the integrity of the genetic material.

ATF4P4 has also been shown to be involved in the regulation of cell signaling pathways, including the TGF-β signaling pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development and progression of many diseases, including cancer.

In addition to its role in the TGF-β signaling pathway, ATF4P4 has also been shown to be involved in the regulation of the NF-kappa-B signaling pathway, a critical pathway involved in inflammation and immune responses.

ATF4P4 has also been shown to play a role in the regulation of cell adhesion and migration. This is an important aspect of cell biology, as cell adhesion and migration are involved in the development and progression of many diseases, including cancer.

In addition to its role in cell adhesion and migration, ATF4P4 has also been shown to play a role in the regulation of cell signaling pathways, including the TGF-β signaling pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development and progression of many diseases, including cancer.

In conclusion, ATF4P4 is a protein that has been shown to play a role in a variety of cellular processes, including the regulation of protein synthesis and turnover, DNA replication and repair, cell survival, and the regulation of the DNA damage response, TGF-β signaling pathway, and NF-kappa-B signaling pathway. Its research has important implications for the development and treatment of a variety of diseases.

Protein Name: Activating Transcription Factor 4 Pseudogene 4

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