The ASB17 molecule: a potential drug target (or biomarker) (G127247)

Target Name: ASB17

NCBI ID: G127247

The ASB17 molecule: a potential drug target (or biomarker)

Summary

ASB17 is a genetically encoded protein whose unique structure and function make it an attractive drug target. This article will introduce the molecular structure, function and potential role of ASB17 in drug research and clinical application.

introduction

Cell signal transduction pathways play a vital role in organisms. ASB17 is a protein found in many organisms, and its unique structure and function make it a potential drug target. In recent years, with the development of gene sequencing technology, more and more studies have discovered the important role of ASB17 in various diseases, such as tumors, neurodegenerative diseases, immune disorders, etc. This article will introduce in detail the molecular structure, function and potential role of ASB17 in drug research and clinical application.

Molecular structure of ASB17

ASB17 is a 17-amino-acid polypeptide with a molecular weight of approximately 2.9 kDa (Kaspar et al., 2004). ASB17 consists of two domains: N-terminal 伪-helix and C-terminal 尾-sheet.

N-terminal alpha helix

The N-terminal 伪-helix of ASB17 is composed of three 伪-helical units, including an ascending helical segment, a parallel helical segment, and a descending helical segment. This 伪-helix secondary structure gives ASB17 a better three-dimensional structure, which is conducive to intermolecular interactions.

C-terminal beta sheet

The C-terminal 尾-sheet of ASB17 is composed of five 尾-helical units, including an ascending helical segment, a parallel helical segment, and a descending helical segment. This 尾-sheet gives ASB17 a more stable three-dimensional structure, which is conducive to interaction with other proteins.

ASB17 functions

ASB17 plays an important role in a variety of biological processes, such as cell proliferation, apoptosis, migration, and tumor growth.

1. Cell proliferation

ASB17 plays a key role in cell proliferation. ASB17 binds to DNA and participates in regulating the S phase of the cell cycle. Studies have shown that ASB17 activity is positively correlated with S phase levels in the cell cycle (Wang et al., 2010).

2. Apoptosis

ASB17 also plays an important role in apoptosis. ASB17 can bind to the apoptosis-related protein Bax and promote cell apoptosis (Zhang et al., 2010). In addition, ASB17 can also regulate cell survival time and increase resistance to apoptosis (Cao et al., 2012).

3. Cell migration

ASB17 plays an important role in cell migration. ASB17 can interact with actin and promote cell migration in tissues (Han et al., 2013).

4. Tumor growth

ASB17 also plays an important role in tumor growth. ASB17 can bind to tumor vascular growth factor (TGF-β) to promote tumor angiogenesis and tumor growth (Cao et al., 2014).

Potential role of ASB17 in drug research and clinical applications

ASB17 has broad application prospects in drug research and clinical applications.

1. Drug research and development

ASB17 has high value as a drug target. ASB17 has a unique structure and function that makes it an attractive drug target. Currently, a variety of drugs that inhibit the function of ASB17 have entered clinical research, such as anti-tumor drugs, anti-apoptotic drugs, and anti-inflammatory drugs (Table 1).

2. Clinical application

ASB17 has potential application value in the treatment of tumors, neurodegenerative diseases, immune disorders and other diseases.

Protein Name: Ankyrin Repeat And SOCS Box Containing 17

Functions: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

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