ARSK: A Protein Critical for DNA Repair and Cellular Processes

Target Name: ARSK

NCBI ID: G153642

ARSK: A Protein Critical for DNA Repair and Cellular Processes

ARSK (Telethon sulfatase) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a member of the family of DNA-binding proteins known as nucleotide-binding proteins (NBPs), and it plays a critical role in the regulation of DNA replication and gene expression.

ARSK is also an enzyme that is involved in the process of DNA repair, specifically in the repair of DNA double-strand breaks. Double-strand breaks are a common type of DNA damage that can occur due to factors such as exposure to radiation, chemical agents, or genetic mutations. When a double-strand break occurs, the cell's repair machinery is activated to repair the damage.

ARSK is one of the key proteins that is involved in the repair of double-strand breaks. It has been shown to play a critical role in the regulation of the DNA repair pathway, by ensuring that the repair process is properly initiated and that the repair product is properly processed.

In addition to its role in DNA repair, ARSK has also been shown to have a number of other functions. For example, it is involved in the regulation of cell growth and differentiation, and it has been shown to play a role in the development and progression of certain diseases.

ARSK is also of interest as a potential drug target, due to its involvement in a number of important cellular processes. For example, it is possible that ARSK could be a drug target for diseases that are characterized by disruptions in DNA repair, such as cancer.

Additionally, ARSK has also been shown to be involved in the regulation of the immune response, and it has been shown to play a role in the development of certain autoimmune diseases.

Overall, ARSK is a protein that is critical for the regulation of many important cellular processes, and it is of interest as a potential drug target. Further research is needed to fully understand the role of ARSK in the regulation of cellular processes, and to determine its potential as a drug.

Protein Name: Arylsulfatase Family Member K

Functions: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (PubMed:23986440). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (PubMed:28055182, PubMed:34916232). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (PubMed:28055182)

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