ARRDC1: A Potential Drug Target and Biomarker (G92714)

Target Name: ARRDC1

NCBI ID: G92714

ARRDC1: A Potential Drug Target and Biomarker

Arrestin domain-containing protein 1 (ARRDC1) is a protein that is expressed in various tissues and cells of the human body. It is a member of the arrestin family of proteins, which are known for their role in intracellular signaling pathways.Expression of ARRDC1 has been observed in a variety of tissues, including brain, heart, liver, and pancreas, and its function is still poorly understood.

Potential Drug Target

ARRDC1 has been identified as a potential drug target due to its involvement in several cellular processes that are associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its functions in intracellular signaling pathways have been implicated in the regulation of cell survival, proliferation, and migration.

ARRDC1 has been shown to play a role in several signaling pathways that are involved in cancer progression, including the TGF-β pathway, which is a well-established pathway for cancer development. In addition, ARRDC1 has been shown to be involved in the regulation of cell migration and the establishment of cancer stem cell properties.

Biomarker

ARRDC1 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its expression has been observed in a variety of tissues, including cancer, brain, and heart, and its levels have been shown to be elevated in these tissues in association with the disease.

ARRDC1 has also been shown to play a role in the regulation of inflammation, which is a key aspect of several diseases, including cancer and neurodegenerative diseases. Its expression has been observed in tissues that are involved in inflammation, including brain and heart.

Conclusion

In conclusion, ARRDC1 is a protein that has been identified as a potential drug target and biomarker. Its functions in intracellular signaling pathways have been implicated in the regulation of cell survival, proliferation, and migration, as well as the regulation of cancer progression, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of ARRDC1 in these processes and its potential as a drug target and biomarker.

Protein Name: Arrestin Domain Containing 1

Functions: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940)

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