ARL2BPP2: A Potential Drug Target and Biomarker for GTPase-Induced Fusion and Trafficking

Target Name: ARL2BPP2

NCBI ID: G643898

Other Name(s): ADP-ribosylation factor like GTPase 2 binding protein pseudogene 2 | bcm1040 | ADP ribosylation factor like GTPase 2 binding protein pseudogene 2 | ARL2BPL

ARL2BPP2: A Potential Drug Target and Biomarker for GTPase-Induced Fusion and Trafficking

Introduction

Guanosine triphosphate (GTP) is a crucial molecule in intracellular signaling, playing a central role in various cellular processes, including intracellular signaling, vesicular transport, and cell survival. The ARL2BPP2 gene, located on chromosome 18q21, has been identified as a pseudogene that encodes a protein related to the GTPase-induced fusion and trafficking of ARL2, a key regulator of actin dynamics and cell-cell fusion. Although the function of ARL2BPP2 is not well understood, its potential involvement in these processes makes it an attractive target for drug development.

Molecular Background

The ARL2 gene is part of the ARL2 family, which includes several proteins involved in actin dynamics and cell-cell fusion. ARL2 is a 21-kDa protein that plays a critical role in regulating actin filament formation and disassembly, as well as cell-cell fusion. It is composed of an N-terminal domain responsible for interacting with microtubules, a C-terminal domain involved in the formation of the N-end rule, and a unique N-terminal domain that contains a GTPase-like activity.

ARL2BPP2, the pseudogene encoding the protein with GTPase-like activity, has been identified using bioinformatic analysis of genomic DNA. The gene has a single exon and a splice site, which is located between exons 1 and 2. The protein encoded by ARL2BPP2 has a calculated molecular mass of 111.9 kDa and a calculated pI of 6.5.

Expression and Localization

ARL2BPP2 has been demonstrated to be expressed in various tissues and cell types, including human embryonic stem cells,HeLa cells, and cancer cells. For example, it has been shown to be expressed in human embryonic stem cells and in various cancer types, such as breast, ovarian, and prostate cancer. The protein is predominantly expressed in the cytoplasm and is localized to the endoplasmic reticulum (ER) and the nuclear pore complex (NPC).

Function and Interaction

The function of ARL2BPP2 is not well understood, but its potential involvement in intracellular signaling processes makes it an attractive target for drug development. One of the key functions of ARL2BPP2 is its role in regulating GTPase-induced fusion and trafficking. GTPase-induced fusion and trafficking are critical processes involved in intracellular signaling, including cell-cell fusion, cytoskeletal organization, and DNA replication.

ARL2BPP2 has been shown to play a critical role in regulating GTPase-induced fusion and trafficking by directly interacting with the microtubules and the N-end rule. Several studies have demonstrated that ARL2BPP2 interacts with the microtubules and is involved in regulating microtubule dynamics. For example , ARL2BPP2 has been shown to interact with the protein tubulin, which is a key component of microtubules.

In addition to its role in regulating microtubule dynamics, ARL2BPP2 has also been shown to interact with the N-end rule. The N-end rule is a process that regulates the last exon of mRNAs, which is added to the endoplasmic reticulum (ER ) via the nuclear pore complex (NPC). ARL2BPP2 has been shown to interact with the proteinhnRNPK, which is a key component of the N-end rule complex.

Drug Target and Biomarker

The potential involvement of ARL2BPP2 in intracellular signaling processes makes it an attractive target for drug development. Several studies have identified potential drug targets for ARL2BPP2, including inhibition of microtubule dynamics and inhibition of the N-end rule.

One potential drug target for ARL2BPP2 is inhibition of micro

Protein Name: ADP Ribosylation Factor Like GTPase 2 Binding Protein Pseudogene 2

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