ARHGAP35: A Potential Drug Target and Biomarker (G2909)

Target Name: ARHGAP35

NCBI ID: G2909

ARHGAP35: A Potential Drug Target and Biomarker

ARHGAP35 is a gene that encodes a protein involved in the armadillo repeat-containing G protein-coupled receptor (ARG) signaling pathway. The ARG protein is a key regulator of cellular processes such as cell survival, proliferation, and migration. The dysfunction of ARG signaling has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Therefore, targeting ARHGAP35 may provide new insights into the pathogenesis of these diseases and may lead to the development of new therapeutic strategies.

Drug Targets

ARHGAP35 can be potential drug targets due to its unique structure and its involvement in various cellular processes. The armadillo repeat is a conserved motif that is found in various proteins, including ARG, which is involved in the regulation of protein function and stability. Therefore, drugs that can inhibit the activity of ARHGAP35 or its downstream targets may be useful in treating diseases associated with ARG signaling pathway dysfunction.

One potential drug that may target ARHGAP35 is a small molecule inhibitor, which can be administered to animals or humans to disrupt the activity of ARHGAP35. This inhibitor can then be used to treat diseases that are characterized by the dysregulation of ARG signaling pathway. For example, ARHGAP35 has been implicated in the development and progression of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Therefore, inhibitors of ARHGAP35 may be useful in treating these diseases.

Biomarkers

ARHGAP35 can also be used as a biomarker to diagnose and monitor diseases associated with the dysregulation of ARG signaling pathway. The expression of ARHGAP35 is regulated by various factors, including cytokines, chemokines, and hormones. Therefore, the level of ARHGAP35 expression can be used as a biomarker to diagnose and monitor diseases that are characterized by the dysregulation of ARG signaling pathway.

ARHGAP35 has been shown to be involved in the regulation of cellular processes such as cell survival, proliferation, and migration. Therefore, the level of ARHGAP35 expression may be used as a biomarker to diagnose and monitor diseases associated with the dysregulation of ARG signaling pathway. For example, low levels of ARHGAP35 expression may be indicative of neurodegenerative diseases, while high levels of ARHGAP35 expression may be indicative of cancer.

Conclusion

In conclusion, ARHGAP35 is a gene that encodes a protein involved in the armadillo repeat-containing G protein-coupled receptor (ARG) signaling pathway. The ARG protein is a key regulator of cellular processes such as cell survival, proliferation, and migration. The dysfunction of ARG signaling pathway has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Therefore, targeting ARHGAP35 may provide new insights into the pathogenesis of these diseases and may lead to the development of new therapeutic strategies. Additionally, ARHGAP35 can be potential drug targets and biomarkers for treating these diseases.

Protein Name: Rho GTPase Activating Protein 35

Functions: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621)

More Common Targets