GLI1: Zinc Finger Protein Regulates Gene Expression, DNA Structure, Cell Cycle, Apoptosis and Metabolism

Target Name: GLI1

NCBI ID: G2735

GLI1: Zinc Finger Protein Regulates Gene Expression, DNA Structure, Cell Cycle, Apoptosis and Metabolism

GLI1 (Zinc finger protein GLI1 (isoform 2)) is a protein that is expressed in almost all eukaryotic cells and plays an important role in many biological processes. GLI1 is a zinc finger transcription factor that is mainly involved in regulating gene expression and DNA structure. Its functions have been extensively studied, especially in biological processes such as neural development, cell differentiation, cell cycle regulation, apoptosis, immune response, and metabolism.

The function of GLI1 is mainly reflected in its zinc finger structure. Zinc fingers are a special protein structure in which multiple amino acid residues are combined through hydrogen bonds to form a helical structure. This structure allows zinc fingers to bind to specific sequences on DNA and participate in a series of biological processes.

The zinc finger structure of GLI1 enables it to bind to specific sequences on DNA. The hydrogen bonding site in the zinc finger structure is the key site for GLI1 to bind to DNA. These binding sites usually interact with specific sequences on DNA and are involved in gene expression and DNA structure. For example, the zinc finger structure of GLI1 can bind to the promoters of certain genes, thereby regulating gene expression. In addition, the zinc finger structure of GLI1 can also bind to specific sequences on DNA and participate in the DNA structure. This binding can lead to changes in the function of GLI1, thereby affecting gene expression and DNA structure.

The function of GLI1 is also reflected in its regulation of the cell cycle. GLI1 is an important component of cyclin kinase (CKP) in the cell cycle. CKP is a class of proteins that play important roles in the cell cycle. They can participate in different stages of the cell cycle, including G1/S, S, G2/M and G0/G1 phases. GLI1 is the main component of CKP6 and can participate in the regulation of cell cycle together with CKP6.

The function of GLI1 is also reflected in its regulation of apoptosis. GLI1 is an important player in the apoptosis process. Apoptosis is an important way of cell death and plays an important role in biological processes such as neural development, tissue repair, and immune response. GLI1 functions by regulating apoptosis. For example, the function of GLI1 can lead to the occurrence of apoptosis, thereby maintaining the homeostasis of tissues and organs.

The function of GLI1 is also reflected in its regulation of immune responses. GLI1 is an important player in immune responses. It can participate in the differentiation and functional regulation of immune cells, thereby participating in the regulation of immune responses. For example, GLI1 function can lead to the differentiation of immune cells, thereby enabling them to fight against foreign substances.

The function of GLI1 is also reflected in its regulation of metabolism. GLI1 is involved in glucose and fatty acid metabolism. It can participate in the key processes of glucose and fatty acid metabolism, thus affecting

Protein Name: GLI Family Zinc Finger 1

Functions: Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24076122, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407)

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