T Cell Receptor Alpha Variable 26-2: Protein Involved in Immune Surveillance and Cell Signaling

Target Name: TRAV26-2

NCBI ID: G28656

Other Name(s): T cell receptor alpha variable 26-2 | TCRAV26S2 | TCRAV4S1 | TRAV262

T Cell Receptor Alpha Variable 26-2: Protein Involved in Immune Surveillance and Cell Signaling

T cell receptor alpha variable 26-2 (TRAV26-2) is a protein that is expressed in various tissues of the body, including the spleen, lung, heart, kidneys, and gastrointestinal tract. It is a type of protein that is derived from the extracellular domain of the T cell receptor alpha chain, which is a protein that is responsible for recognizing and responding to foreign antigens in the body.

TRAV26-2 is a 26-kDa protein that is expressed in various tissues of the body. It is highly expressed in the spleen, lung, heart, kidneys, and gastrointestinal tract, and is also found in the skin, lymph nodes, and spleen. It is a type of protein that is derived from the extracellular domain of the T cell receptor alpha chain, which is a protein that is responsible for recognizing and responding to foreign antigens in the body.

One of the key functions of T cell receptor alpha variable 26-2 is that it is involved in the process of immune surveillance. T cells are a type of white blood cell that are responsible for protecting the body against infection and disease. T cell receptor alpha variable 26-2 is part of the T cell receptor alpha chain, which is responsible for recognizing and responding to foreign antigens in the body. T cell receptor alpha variable 26-2 is highly expressed in the spleen, lung, heart, kidneys, and gastrointestinal tract, which are all tissues that are involved in the process of immune surveillance.

Another function of T cell receptor alpha variable 26-2 is that it is involved in the regulation of inflammation. Inflammation is a natural response of the immune system to injury or infection. T cell receptor alpha variable 26-2 is involved in the regulation of inflammation because it is a receptor that is involved in the process of immune surveillance. When the body detects a foreign antigen, T cell receptor alpha variable 26-2 is activated and tells the immune system to launch an immune response.

In addition to its role in immune surveillance and regulation of inflammation, T cell receptor alpha variable 26-2 is also involved in the process of cell signaling. T cells are a type of white blood cell that are responsible for protecting the body against infection and disease. T cell receptor alpha variable 26-2 is part of the T cell receptor alpha chain, which is a protein that is responsible for recognizing and responding to foreign antigens in the body. T cell receptor alpha variable 26-2 is highly expressed in the spleen, lung, heart, kidneys, and gastrointestinal tract, which are all tissues that are involved in the process of immune surveillance.

T cell receptor alpha variable 26-2 is also involved in the regulation of cell signaling because it is a receptor that is involved in the process of immune surveillance. When the body detects a foreign antigen, T cell receptor alpha variable 26-2 is activated and tells the immune system to launch an immune response. T cell receptor alpha variable 26-2 is a protein that is derived from the extracellular domain of the T cell receptor alpha chain, which is a protein that is responsible for recognizing and responding to foreign antigens in the body.

In conclusion, T cell receptor alpha variable 26-2 is a protein that is expressed in various tissues of the body. It is highly expressed in the spleen, lung, heart, kidneys, and gastrointestinal tract, and is also found in the skin, lymph nodes, and spleen. T cell receptor alpha variable 26-2 is involved in the process of immune surveillance and regulation of inflammation because it is a receptor that is involved in the process of immune surveillance. It is also involved in the regulation of cell signaling because it is a receptor that is involved in the process of immune surveillance.

Protein Name: T Cell Receptor Alpha Variable 26-2

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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