EPN1: A Potential Drug Target and Biomarker for Mitosis-Induced Proteasomal Degradation

Target Name: EPN1

NCBI ID: G29924

EPN1: A Potential Drug Target and Biomarker for Mitosis-Induced Proteasomal Degradation

Introduction

Mitosis is a critical process in cell division that ensures the transmission of genetic information from one generation to the next. In mitosis, chromosomes separate under the guidance of the spindle and move to the extreme ends of the cell, eventually forming two new cells. However, in some cases, abnormal cell division can lead to tumor formation. Therefore, it is of great biological significance to study the molecular mechanisms that regulate chromosome segregation and cell fate during mitosis.

EPN1 (EH domain-binding mitotic phosphoprotein) is a protein belonging to the HSP70 family and plays an important role in the mitosis process. It plays a key role in spindle assembly, chromosome segregation, and the progression of cell mitosis. In addition, EPN1 also binds to components such as tubulin and centriolar proteins and participates in regulating the formation of spindle structure and function.

In recent years, researchers have conducted in-depth studies on the function of EPN1 and found that its expression is up-regulated in a variety of tumors and has the potential to be a potential drug target. At the same time, EPN1 also serves as a biomarker for protein expression in tumor tissues and can be used for tumor diagnosis and treatment evaluation.

Biological functions of EPN1

EPN1 is a transmembrane protein, and its encoding gene is NSP2.3. It plays an important role in the mitotic phase of the cell cycle. During prophase of mitosis, EPN1 binds to tubulin, promotes the assembly of tubulin, and thereby participates in the formation of the spindle structure. During metaphase of mitosis, EPN1 binds to spindle tubulin and functions on spindle fibers to facilitate chromosome segregation. During late mitosis, EPN1 participates in the movement of chromosomes on spindle fibers and helps chromosomes reach cellular extremes.

In addition, EPN1 is also involved in other stages of the cell cycle. It binds to ribosomes in the G1 phase and participates in the binding of RNA polymerase in the S phase to provide support for gene expression. During the G2 phase, EPN1 binds to centriolar proteins, participates in the assembly and separation of spindle fibers, and promotes centriolar-spindle interactions. During prophase of mitosis, EPN1 binds to histones and contributes to the assembly of histones, thereby participating in the tight packaging of chromosomes.

Tumor expression of EPN1

EPN1 expression is up-regulated in a variety of tumors, such as breast cancer, lung cancer, prostate cancer, and ovarian cancer. Studies have shown that the expression level of EPN1 is positively correlated with tumor aggressiveness and treatment response. In addition, the expression level of EPN1 is also related to the survival rate of tumor patients. Therefore, EPN1, as a potential drug target for tumors, has high clinical application value.

Biomarker value of EPN1

EPN1 also serves as a biomarker of protein expression in tumor tissues and can be used for tumor diagnosis and treatment evaluation. For example, in breast cancer patients, EPN1 expression levels are positively correlated with tumor aggressiveness and treatment response. By detecting the expression level of EPN1, the survival rate and treatment effect of breast cancer patients can be predicted, and guidance for personalized treatment of breast cancer can be provided.

In addition, EPN1 is also related to the degree of immune cell infiltration in tumor tissues. Studies have shown that the degree of immune cell infiltration in tumor tissue is positively correlated with the expression level of EPN1, which provides a basis for immune escape of tumor tissue. Therefore, by detecting the expression level of EPN1, the degree of immune evasion of tumor tissue can be evaluated and provide guidance for tumor immunotherapy.

in conclusion

EPN1 is a protein that plays an important role in the mitosis process. Its upregulated expression in tumors provides important biological significance as a biomarker of protein expression in tumor tissue and immune evasion. Therefore, EPN1 is a potential drug target and can be used as a biomarker for tumor diagnosis and treatment evaluation. Future research should further study the mechanism of EPN1 in the mitosis process in order to bring new progress in tumor treatment.

Protein Name: Epsin 1

Functions: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179)

More Common Targets