Understanding The Role of MRM2 in Disease (G29960)

Target Name: MRM2

NCBI ID: G29960

Understanding The Role of MRM2 in Disease

MRM2 (MutL homolog 2) is a gene that encodes a protein known as MRM2_HUMAN. It is a member of the MIM (MutL homolog 2) gene family, which is a family of proteins that are involved in the regulation of DNA double-strand break repair.

The MRM2 gene is located on chromosome 18 and encodes a protein that is composed of 211 amino acid residues. The protein has several important functions, including the repair of double-strand breaks in DNA, the protection against radiation-induced DNA damage, and the regulation of the cell cycle.

One of the unique features of MRM2 is its ability to form a complex with the protein p53, which is a well-known tumor suppressor protein. This complex plays a critical role in the regulation of DNA double-strand break repair and is a potential drug target for cancer therapies.

In addition to its role in DNA repair, MRM2 has also been shown to be involved in the regulation of cell growth and apoptosis. It has been shown to play a negative role in the regulation of cell cycle progression and to be involved in the inhibition of cell proliferation.

The potential drug targets for MRM2 are numerous and range from inhibition of DNA repair to inhibition of cell growth and apoptosis. These drug targets are of particular interest to researchers because they can lead to the development of new treatments for a wide range of diseases, including cancer.

In conclusion, MRM2 is a gene that encodes a protein that is involved in the regulation of DNA double-strand break repair, cell growth, and apoptosis. Its unique ability to form a complex with the tumor suppressor protein p53 makes it a potential drug target for cancer therapies. Further research is needed to fully understand the role of MRM2 in disease and to develop effective treatments.

Protein Name: Mitochondrial RRNA Methyltransferase 2

Functions: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA

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