MROH8: Potential Drug Target for Cancer and Other Diseases (G140699)

Target Name: MROH8

NCBI ID: G140699

MROH8: Potential Drug Target for Cancer and Other Diseases

MROH8 (Protein MROH8 (isoform 1)) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the MROH (Mammalian Retinoblastoma 1) family of proteins, which are known for their role in the development and progression of certain diseases, such as cancer.

MROH8 is a 21-kDa protein that is composed of 115 amino acid residues. It has a characteristic topology, with a long N-terminus that is involved in protein-protein interactions and a short C-terminus that is involved in carbohydrate recognition. MROH8 is predominantly expressed in the brain, with lower levels found in the heart and kidneys.

MROH8 has been shown to play a role in several physiological processes in the body, including cell survival, growth, and differentiation. It has been shown to be involved in the development and progression of certain diseases, such as cancer, and has been identified as a potential drug target.

One of the key functions of MROH8 is its role in cell survival and growth. MROH8 has been shown to play a role in the regulation of cell survival by promoting the production of mitochondrial derived signaling pathways, such as the TOR signaling pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and MROH8 has been shown to be involved in the inhibition of this pathway in cancer cells.

Another function of MROH8 is its role in cell signaling. MROH8 has been shown to play a role in the regulation of cell signaling by interacting with several different signaling pathways, including the PI3K/Akt signaling pathway and the TGF-β signaling pathway. These signaling pathways are involved in the regulation of cell growth, differentiation, and survival, and MROH8 has been shown to be involved in the regulation of these pathways in cancer cells.

MROH8 has also been shown to play a role in the regulation of cellular interactions and adhesion. MROH8 has been shown to interact with several different proteins, including the cadherin protein, which is involved in cell-cell adhesion. This interaction between MROH8 and cadherin has been shown to play a role in the regulation of cell-cell adhesion and the development of certain diseases, such as cancer.

In addition to its role in cell survival and signaling, MROH8 has also been shown to play a role in the regulation of cellular processes such as cell division and apoptosis. MROH8 has been shown to play a role in the regulation of cell division by promoting the production of cyclin D1, which is involved in the regulation of cell cycle progression. MROH8 has also been shown to play a role in the regulation of apoptosis, which is the process by which cells undergo programmed cell death. This interaction between MROH8 and apoptosis has been shown to play a role in the regulation of cellular processes and the development of certain diseases, such as cancer.

MROH8 has also been shown to play a role in the regulation of inflammation. MROH8 has been shown to interact with several different signaling pathways, including the NF-kappa-B signaling pathway, which is involved in the regulation of inflammation. This interaction between MROH8 and NF-kappa-B has been shown to play a role in the regulation of inflammation and the development of certain diseases, such as cancer.

In conclusion, MROH8 is a protein that is involved in several physiological processes in the body, including cell survival, growth, and differentiation. It has been shown to play a role in the regulation of cell signaling pathways, cell division, apoptosis, and inflammation. As a result, MROH8 is a potential drug target for the treatment of a wide range of diseases. Further research is needed to fully understand the role of MROH8 in

Protein Name: Maestro Heat Like Repeat Family Member 8

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