Target Name: ZNF445
NCBI ID: G353274
Other Name(s): ZNF445 variant 1 | ZSCAN47 | ZNF168 | Zinc finger protein 445 (isoform 1) | ZFP445 | zinc finger protein 445 | Zinc finger protein 168 | ZN445_HUMAN | ZKSCAN15 | Zinc finger protein 445, transcript variant 1 | zinc finger protein 168 | zinc finger protein with KRAB and SCAN domains 15 | Zinc finger protein 445 | Zinc finger protein with KRAB and SCAN domains 15

ZNF41: A Potential Drug Target for Psychiatric Disorders

ZNF445 (ZNF445 variant 1) is a gene that encodes for a protein known as ZNF41, which is a key regulator of neural development and function. The ZNF41 protein plays a vital role in the regulation of stem cell proliferation, differentiation, and survival, and is implicated in a wide range of neurodevelopmental and psychiatric disorders.

Recent studies have identified ZNF41 as a potential drug target for the treatment of various psychiatric disorders, including depression, anxiety, and schizophrenia. ZNF41 has also been shown to be involved in the regulation of pain perception and anxiety, and may have a role in the development of chronic pain.

The ZNF41 protein is expressed in many different tissues and cells in the body, including the brain, and is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and survival. It is a key regulator of stem cell proliferation and maintenance, and has been shown to play a role in the regulation of neural stem cell survival and proliferation.

In addition to its role in stem cell biology, ZNF41 is also involved in the regulation of tissue repair and regeneration. It has been shown to play a role in the regulation of wound healing and tissue regeneration, and may have a potential role in the treatment of wound healing disorders.

The ZNF41 protein is also involved in the regulation of protein synthesis and metabolism. It has been shown to play a role in the regulation of protein synthesis and degradation, and may be involved in the treatment of diseases that are characterized by the overproduction or underproduction of certain proteins.

In conclusion, ZNF41 is a gene that has a wide range of potential applications as a drug target. Its involvement in the regulation of stem cell biology, tissue repair and regeneration, and protein synthesis and metabolism makes it an attractive target for the development of new treatments for a wide range of psychiatric and neurological disorders. Further research is needed to fully understand the role of ZNF41 in neural development and function, and to develop safe and effective treatments for the disorders associated with its dysfunction.

Protein Name: Zinc Finger Protein 445

Functions: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440)

More Common Targets

ZNF446 | ZNF449 | ZNF45 | ZNF451 | ZNF454 | ZNF460 | ZNF461 | ZNF462 | ZNF467 | ZNF468 | ZNF469 | ZNF470 | ZNF471 | ZNF473 | ZNF473CR | ZNF479 | ZNF48 | ZNF480 | ZNF483 | ZNF484 | ZNF485 | ZNF486 | ZNF487 | ZNF488 | ZNF490 | ZNF491 | ZNF492 | ZNF493 | ZNF496 | ZNF497 | ZNF497-AS1 | ZNF500 | ZNF501 | ZNF502 | ZNF503 | ZNF503-AS1 | ZNF503-AS2 | ZNF506 | ZNF507 | ZNF510 | ZNF511 | ZNF512 | ZNF512B | ZNF513 | ZNF514 | ZNF516 | ZNF516-DT | ZNF517 | ZNF518A | ZNF518B | ZNF519 | ZNF519P3 | ZNF521 | ZNF524 | ZNF525 | ZNF526 | ZNF527 | ZNF528 | ZNF528-AS1 | ZNF529 | ZNF529-AS1 | ZNF530 | ZNF532 | ZNF534 | ZNF536 | ZNF540 | ZNF541 | ZNF542P | ZNF543 | ZNF544 | ZNF546 | ZNF547 | ZNF548 | ZNF549 | ZNF550 | ZNF551 | ZNF552 | ZNF554 | ZNF555 | ZNF556 | ZNF557 | ZNF558 | ZNF559 | ZNF559-ZNF177 | ZNF560 | ZNF561 | ZNF561-AS1 | ZNF562 | ZNF563 | ZNF564 | ZNF565 | ZNF566 | ZNF566-AS1 | ZNF567 | ZNF568 | ZNF569 | ZNF56P | ZNF57 | ZNF570 | ZNF571