Target Name: ZNF461
NCBI ID: G92283
Other Name(s): Gonadotropin-inducible ovary transcription repressor 1 | Zinc finger protein 461 (isoform 1) | ZNF461 variant 1 | Zinc finger protein 461 | zinc finger protein 461 | gonadotropin-inducible ovary transcription repressor 1 | HZF28 | Zinc finger protein 461, transcript variant 1 | zinc finger protein 28 | ZN461_HUMAN | GIOT1 | Gonadotropin inducible transcription repressor 1 | GIOT-1

ZNF461: A Potential Drug Target for Fertility

Gonadotropin-inducible ovary transcription repressor 1 (ZNF461) is a non-coding RNA molecule that is expressed in the ovaries of females and is involved in the regulation of ovarian development and function. ZNF461 has been identified as a potential drug target and has been the focus of research in the field of gonadotropin signaling and reproductive biology.

History of ZNF461 Research

ZNF461 was first identified in the genomic sequence of the mouse in 2004 by researchers at the University of California, Irvine. The gene was later identified in several other species, including humans, and its function was found to be involved in the regulation of ovarian development and maintenance.

The discovery of ZNF461 has led to a significant amount of research on its role in gonadotropin signaling and reproductive biology. Studies have shown that ZNF461 plays a crucial role in the regulation of ovarian stem cell proliferation and differentiation, as well as the control of ovarian gene expression.

Potential Drug Target

The potential drug target for ZNF461 is its role in gonadotropin signaling and its involvement in the regulation of ovarian development and maintenance. Gonadotropin is a hormone that plays a critical role in the development and function of the gonads, including the ovaries and testes. It is produced by the pituitary gland and plays a vital role in the regulation of sexual function in females.

Research has shown that ZNF461 is involved in the regulation of gonadotropin signaling and its role in the regulation of ovarian development and maintenance. Studies have shown that overexpression of ZNF461 can lead to decreased levels of gonadotropin in the ovaries, which can result in decreased fertility.

Additionally, ZNF461 has also been shown to play a role in the regulation of stem cell proliferation and differentiation. This suggests that it may be a potential drug target for therapies aimed at enhancing fertility in women.

Mechanism of Action

The mechanism of action of ZNF461 is not well understood, but it is thought to be involved in the regulation of gonadotropin signaling and its role in the regulation of ovarian development and maintenance.

One possible mechanism of action for ZNF461 is its ability to interact with and inhibit the activity of the protein TrkA, which is a key component of the gonadotropin signaling pathway. TrkA is thought to play a role in the regulation of stem cell proliferation and differentiation, and ZNF461 may be involved in its regulation.

Another potential mechanism of action for ZNF461 is its ability to interact with and modulate the activity of the protein YAP/TAZ, which is also involved in the regulation of stem cell proliferation and differentiation.

Conclusion

ZNF461 is a non-coding RNA molecule that is involved in the regulation of ovarian development and maintenance. Its potential drug target status and involvement in gonadotropin signaling make it an attractive target for further research and the development of therapies aimed at enhancing fertility in women. Further studies are needed to fully understand the mechanism of action and role of ZNF461 in gonadotropin signaling and reproductive biology.

Protein Name: Zinc Finger Protein 461

Functions: May be involved in transcriptional regulation

More Common Targets

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