MAN1A1: A Potential Drug Target for Brain and Inflammation (G4121)

Target Name: MAN1A1

NCBI ID: G4121

MAN1A1: A Potential Drug Target for Brain and Inflammation

MAN1A1, also known asmannosidase alpha class 1A member 1, is a protein that is expressed in a variety of tissues throughout the body. It is a member of the MAN1A family of proteins, which are involved in the intracellular manipulation of meninges, the protective membranes that cover the brain and spinal cord.

One of the unique features of MAN1A1 is its catalytic activity, which allows it to catalyze the hydrolysis of specific sugar molecules, such as mannose and glutose. This catalytic activity makes MAN1A1 an attractive drug target, as it can be targeted directly with small molecules.

In addition to its catalytic activity, MAN1A1 also has several other biological properties that make it an interesting candidate for drug targeting. For example, it is a protein that is expressed in high levels in the brain, and it has been shown to be involved in the development and progression of several neurological disorders, including Alzheimer's disease and Parkinson's disease.

MAN1A1 has also been shown to play a role in the regulation of cellular processes that are important for brain function, such as the regulation of synaptic plasticity and the maintenance of cellular homeostasis. This suggests that it may be a useful target for drugs that are designed to modulate brain function and improve cognitive function.

Another potential mechanism by which MAN1A1 may be targeted is its role in the regulation of inflammation. Studies have shown that MAN1A1 is involved in the regulation of the movement of immune cells through the blood-brain barrier, and it has been shown to play a role in the development of neuroinflammatory diseases. This suggests that targeting MAN1A1 with drugs that are designed to dampen inflammation may be a promising strategy for the treatment of neuroinflammatory diseases.

In conclusion, MAN1A1 is a protein that is expressed in high levels in the brain and is involved in the intracellular manipulation of meninges. Its catalytic activity and involvement in the regulation of cellular processes that are important for brain function make it an attractive candidate for drug targeting. Its role in the regulation of inflammation also suggests that it may be a useful target for the treatment of neuroinflammatory diseases. Further research is needed to fully understand the biology of MAN1A1 and its potential as a drug target.

Protein Name: Mannosidase Alpha Class 1A Member 1

Functions: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

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