MAPK15: Key Regulator of MAPK/ERK Signaling Pathway (G225689)

Target Name: MAPK15

NCBI ID: G225689

MAPK15: Key Regulator of MAPK/ERK Signaling Pathway

MAPK15 (Mitogen-activated protein kinase 15) is a protein that plays a crucial role in cell signaling pathways. It is a key regulator of the MAPK/ERK signaling pathway, which is involved in various cellular processes such as cell growth, differentiation, and response to stimuli. The MAPK/ERK signaling pathway is also known as the RAS/MAPK pathway, and it is a well-established target for many drugs, including anti-cancer drugs.

MAPK15 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and muscle. It is a key regulator of the MAPK/ERK signaling pathway, and it is involved in the regulation of various cellular processes, including cell growth, differentiation, and response to stimuli. The MAPK/ERK signaling pathway is also known as the RAS/MAPK pathway, and it is a well-established target for many drugs, including anti-cancer drugs.

MAPK15 is a protein that is expressed in various tissues, including brain, heart, and muscle. It is a key regulator of the MAPK/ERK signaling pathway, and it is involved in the regulation of various cellular processes, including cell growth, differentiation, and response to stimuli. The MAPK/ERK signaling pathway is also known as the RAS/MAPK pathway, and it is a well-established target for many drugs, including anti-cancer drugs.

One of the well-established functions of MAPK15 is its role in cell signaling pathways. It is a key regulator of the MAPK/ERK signaling pathway, which is involved in various cellular processes such as cell growth, differentiation, and response to stimuli. The MAPK/ERK signaling pathway is also known as the RAS/MAPK pathway, and it is a well-established target for many drugs, including anti-cancer drugs.

MAPK15 is a protein that is involved in the regulation of cellular processes, including cell growth, differentiation, and response to stimuli. It is a key regulator of the MAPK/ERK signaling pathway, which is also known as the RAS/MAPK pathway. This pathway is involved in various cellular processes, including the regulation of cell signaling pathways, and it is a well-established target for many drugs, including anti-cancer drugs.

MAPK15 is a protein that plays a crucial role in cell signaling pathways. It is a key regulator of the MAPK/ERK signaling pathway, which is involved in various cellular processes such as cell growth, differentiation, and response to stimuli. The MAPK/ERK signaling pathway is also known as the RAS/MAPK pathway, and it is a well-established target for many drugs, including anti-cancer drugs.

MAPK15 is a protein that is expressed in various tissues, including brain, heart, and muscle. It is a key regulator of the MAPK/ERK signaling pathway, and it is involved in the regulation of various cellular processes, including cell growth, differentiation, and response to stimuli. The MAPK/ERK signaling pathway is also known as the RAS/MAPK pathway, and it is a well-established target for many drugs, including anti-cancer drugs.

MAPK15 is a protein that is involved in the regulation of cellular processes, including cell growth, differentiation, and response to stimuli. It is a key regulator of the MAPK/ERK signaling pathway, which is also known as the RAS/MAPK pathway. This pathway is involved in various cellular processes, including the regulation of cell signaling pathways, and it is a well-established target for many drugs, including anti-cancer drugs.

In conclusion, MAPK15 is a protein that plays a crucial role in

Protein Name: Mitogen-activated Protein Kinase 15

Functions: Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936)

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