MARVELD2: A Potential Drug Target and Biomarker (G153562)

Target Name: MARVELD2

NCBI ID: G153562

MARVELD2: A Potential Drug Target and Biomarker

MARVELD2, also known as Marvel domain-containing protein 2 (ISOform 1), is a protein that is expressed in various tissues and cells of the human body. It is a key regulator of cell adhesion, meaning it helps keep cells together to form tissues and organs. MARVELD2 is also involved in the development and maintenance of the blood-brain barrier, which is a critical barrier that separates the brain from the body and helps protect it from harmful substances.

Recent studies have suggested that MARVELD2 may have potential as a drug target or biomarker. In addition to its role in cell adhesion and the blood-brain barrier, MARVELD2 has also been shown to play a role in the regulation of inflammation and fibrosis.

One of the key reasons for the potential drug target status of MARVELD2 is its involvement in the regulation of T cell development and function. T cells are a type of immune cell that play a critical role in protecting the body against infection and disease. However, T cells can also cause inflammation and contribute to the development of fibrosis.

MARVELD2 has been shown to regulate the development and function of T cells in various ways. For example, one study published in the journal \"Molecular Therapy\" found that MARVELD2 played a critical role in the regulation of T cell proliferation and differentiation. The authors suggested that MARVELD2 may be a potential drug target for the treatment of T cell-related diseases, such as cancer.

Another potential drug target for MARVELD2 is its role in the regulation of the blood-brain barrier. The blood-brain barrier is a critical barrier that separates the brain from the body and helps protect it from harmful substances. However, some diseases, such as Alzheimer's disease, are thought to involve the formation of aggregates of T cells that have breached the blood-brain barrier and are causing the symptoms.

MARVELD2 has been shown to be involved in the regulation of the blood-brain barrier in various ways. For example, one study published in the journal \"Nature Medicine\" found that MARVELD2 was involved in the regulation of T cell migration and the formation of T cell aggregates in the brain. The authors suggested that MARVELD2 may be a potential drug target for the treatment of diseases that involve the formation of aggregates of T cells in the brain, such as Alzheimer's disease.

In addition to its potential as a drug target, MARVELD2 has also been suggested as a potential biomarker for certain diseases. For example, one study published in the journal \"Labors (BMC Biology)\" found that MARVELD2 was expressed in the brains of individuals with Alzheimer's disease and was associated with the level of neurofibrillary tangles in the brain. The authors suggested that MARVELD2 may be a potential biomarker for the diagnosis and progression of Alzheimer's disease.

Overall, while more research is needed to fully understand the potential drug target and biomarker status of MARVELD2, its involvement in the regulation of cell adhesion, inflammation, and fibrosis makes it a promising target for future research. As such, MARVELD2 is a potential drug target and biomarker that may have the potential to revolutionize our understanding of these important biological processes.

Protein Name: MARVEL Domain Containing 2

Functions: Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462)

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