Target Name: MCM10
NCBI ID: G55388
Other Name(s): homolog of yeast MCM10 | OTTHUMP00000216196 | MCM10_HUMAN | DNA43 | hsMCM10 | MGC126776 | Protein MCM10 homolog | Minichromosome maintenance 10 replication initiation factor, transcript variant 1 | Protein MCM10 homolog (isoform 1) | HsMCM10 | minichromosome maintenance complex component 10 | minichromosome maintenance 10 replication initiation factor | CNA43 | MCM10 minichromosome maintenance deficient 10 | OTTHUMP00000019134 | IMD80 | MCM10 variant 1 | Homolog of yeast MCM10 | PRO2249

MCM10: A Protein Involved in Cellular Processes

MCM10, also known as homolog of yeast MCM10, is a protein that is expressed in the human body and is found in various tissues, including the skin, hair, and nails. It is a member of the MCM (multi-domain condensin) family, which includes proteins that are involved in various cellular processes, including cytoskeletal organization, cell signaling, and cell division.

MCM10 is known for its role in the regulation of cell division and cytoskeletal organization. It is a key component of the condensin complex, which is a protein complex that is involved in the regulation of cell division and cytoskeletal organization. This complex is composed of various proteins, including MCM10, MCM20, and MCM30, which work together to ensure the proper organization and regulation of the cytoskeleton during the cell division process.

MCM10 is also involved in the regulation of cell signaling, specifically in the signaling pathway known as the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development and maintenance of tissues and organs. MCM10 is known to be involved in the regulation of the TGF-β signaling pathway by interacting with the protein Smad6.

In addition to its role in cell signaling and cytoskeletal organization, MCM10 is also involved in the regulation of cell migration and the maintenance of tissue structure. It is a key component of the tight junction, which is a barrier that separates tissues from each other and helps to maintain tissue structure. MCM10 is known to be involved in the regulation of tight junction formation and maintenance by interacting with the protein Zinc Finger N-Endonuclease (ZFN).

MCM10 is also involved in the regulation of cell survival and cytoskeletal organization in the context of diseases such as cancer. It is a known to be involved in the regulation of cell survival and cytoskeletal organization in cancer cells by interacting with the protein p53. MCM10 is also involved in the regulation of cell division in cancer cells by interacting with the protein Ku70.

In conclusion, MCM10 is a protein that is involved in various cellular processes that are critical for the regulation of cell division, cytoskeletal organization, cell signaling, cell migration, and cell survival. Its role in these processes makes MCM10 an attractive drug target and a potential biomarker for various diseases, including cancer. Further research is needed to fully understand the mechanisms of MCM10's role in these processes and to develop effective treatments for these diseases.

Protein Name: Minichromosome Maintenance 10 Replication Initiation Factor

Functions: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359)

More Common Targets

MCM2 | MCM3 | MCM3AP | MCM3AP-AS1 | MCM4 | MCM5 | MCM6 | MCM7 | MCM8 | MCM8-MCM9 complex | MCM9 | MCMBP | MCMDC2 | MCOLN1 | MCOLN2 | MCOLN3 | MCPH1 | MCPH1-AS1 | MCPH1-DT | MCRIP1 | MCRIP2 | MCRS1 | MCTP1 | MCTP2 | MCTS1 | MCTS2 | MCU | MCUB | MCUR1 | MDC1 | MDFI | MDFIC | MDGA1 | MDGA2 | MDH1 | MDH1B | MDH2 | MDK | MDM1 | MDM2 | MDM4 | MDN1 | MDS2 | ME1 | ME2 | ME3 | MEA1 | MEAF6 | MEAF6P1 | MEAK7 | Mechanoelectrical transducer (MET) channel | Mechanosensitive Ion Channel | MECOM | MECOM-AS1 | MeCP1 histone deacetylase (HDAC) complex | MECP2 | MECR | MED1 | MED10 | MED11 | MED12 | MED12L | MED13 | MED13L | MED14 | MED14P1 | MED15 | MED15P8 | MED16 | MED17 | MED18 | MED19 | MED20 | MED21 | MED22 | MED23 | MED24 | MED25 | MED26 | MED27 | MED28 | MED29 | MED30 | MED31 | MED4 | MED4-AS1 | MED6 | MED7 | MED8 | MED9 | MEDAG | Mediator Complex | Mediator of RNA Polymerase II Transcription | MEF2A | MEF2B | MEF2C | MEF2C-AS1 | MEF2C-AS2 | MEF2D | MEFV