Target Name: MCM4
NCBI ID: G4173
Other Name(s): MCM4 minichromosome maintenance deficient 4 | NKCD | DNA replication licensing factor MCM4 | Minichromosome maintenance complex component 4 | minichromosome maintenance complex component 4 | homolog of S. pombe cell devision cycle 21 | CDC54 | MCM4_HUMAN | MGC33310 | minichromosome maintenance deficient 4 | NKGCD | P1-CDC21 | Minichromosome maintenance complex component 4, transcript variant 1 | Minichromosome maintenance deficient 4 | IMD54 | CDC21 | CDC21 homolog | hCdc21 | MCM4 variant 1 | Homolog of S. pombe cell devision cycle 21

MCM4: A Potential Drug Target Or Biomarker

MCM4 (MCM4 minichromosome maintenance deficient 4) is a gene that encodes for a protein known as MCM4. MCM4 is a key component of the minichromosome, which is a small subunit of the eukaryotic chromosome that plays a critical role in the regulation of gene expression. MCM4 is essential for the proper functioning of the minichromosome, and research has identified it as a potential drug target or biomarker for various diseases.

MCM4 functions as a negative regulator of the minichromosome. It interacts with the protein Nespermin and helps to keep it in a state of inactive by inhibiting its phosphorylation. MCM4-Nespermin interactions have been observed in various cellular experiments, and these interactions may play a role in the regulation of gene expression.

In addition to its role in the minichromosome, MCM4 has also been shown to play a role in the regulation of cellular processes such as cell division, apoptosis, and inflammation. MCM4 has been shown to be involved in the regulation of the expression of genes involved. in cell division, such as the cyclin D1 gene, which encodes for the protein cyclin D1. MCM4 has also been shown to play a role in the regulation of apoptosis, as it has been shown to interact with the protein Bcl-2.

MCM4 has also been shown to be involved in the regulation of inflammation. It has also been shown to interact with the protein NF-kappa-B, which is a transcription factor that plays a role in the regulation of inflammation. MCM4 has also been shown to contribute to the regulation of the expression of genes involved in inflammation, such as the transcription factor NF-kappa-B.

Despite its involvement in a number of cellular processes, MCM4 is still a relatively unstudied gene. There are currently no known drugs that target MCM4 directly, and research is still in the early stages of exploring its potential as a drug target or biomarker. However, these early findings suggest that MCM4 may be a promising target for future research.

In conclusion, MCM4 is a gene that encodes for a protein that plays a critical role in the regulation of gene expression and cellular processes such as cell division, apoptosis, and cellular processes. Its interaction with the protein Nespermin suggests that it may be a potential drug target or biomarker for various diseases. Further research is needed to fully understand the role of MCM4 in these processes and to explore its potential as a drug target or biomarker.

Protein Name: Minichromosome Maintenance Complex Component 4

Functions: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510, PubMed:25661590, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425, PubMed:16899510, PubMed:25661590, PubMed:9305914)

More Common Targets

MCM5 | MCM6 | MCM7 | MCM8 | MCM8-MCM9 complex | MCM9 | MCMBP | MCMDC2 | MCOLN1 | MCOLN2 | MCOLN3 | MCPH1 | MCPH1-AS1 | MCPH1-DT | MCRIP1 | MCRIP2 | MCRS1 | MCTP1 | MCTP2 | MCTS1 | MCTS2 | MCU | MCUB | MCUR1 | MDC1 | MDFI | MDFIC | MDGA1 | MDGA2 | MDH1 | MDH1B | MDH2 | MDK | MDM1 | MDM2 | MDM4 | MDN1 | MDS2 | ME1 | ME2 | ME3 | MEA1 | MEAF6 | MEAF6P1 | MEAK7 | Mechanoelectrical transducer (MET) channel | Mechanosensitive Ion Channel | MECOM | MECOM-AS1 | MeCP1 histone deacetylase (HDAC) complex | MECP2 | MECR | MED1 | MED10 | MED11 | MED12 | MED12L | MED13 | MED13L | MED14 | MED14P1 | MED15 | MED15P8 | MED16 | MED17 | MED18 | MED19 | MED20 | MED21 | MED22 | MED23 | MED24 | MED25 | MED26 | MED27 | MED28 | MED29 | MED30 | MED31 | MED4 | MED4-AS1 | MED6 | MED7 | MED8 | MED9 | MEDAG | Mediator Complex | Mediator of RNA Polymerase II Transcription | MEF2A | MEF2B | MEF2C | MEF2C-AS1 | MEF2C-AS2 | MEF2D | MEFV | MEG3 | MEG8 | MEG9 | MEGF10 | MEGF11