MATR3: A Protein Involved in Mitochondrial Function and More (G9782)

Target Name: MATR3

NCBI ID: G9782

MATR3: A Protein Involved in Mitochondrial Function and More

MATR3 (MATR3 variant 1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the MATR family of proteins, which are known for their role in the regulation of mitochondrial function and energy metabolism.

MATR3 is a 21-kDa protein that is composed of 156 amino acid residues. It has a molecular weight of 19,112 Da and a calculated pI of 9.65. MATR3 is expressed in a variety of tissues, including the brain, heart, and kidneys, and is involved in the regulation of mitochondrial function and energy metabolism.

One of the unique features of MATR3 is its ability to interact with various molecules, including co-factors, substrates, and inhibitors. This interactivity allows MATR3 to play a role in a wide range of cellular processes, including metabolism, stress response, and neurodegeneration.

One of the potential drug targets for MATR3 is its role in the regulation of mitochondrial function. MATR3 has been shown to play a role in the regulation of mitochondrial fusion and fusion-protonation, which are processes that are critical for the production of ATP by the mitochondria.

In addition to its role in mitochondrial function, MATR3 is also involved in the regulation of cellular stress responses. It has been shown to play a role in the regulation of the stress response pathways, including the G1-S transition and the G0-G1 transition.

MATR3 is also involved in the regulation of cellular signaling pathways, including the regulation of cell adhesion, angiogenesis, and inflammation. It has been shown to play a role in the regulation of T-cell development and function, as well as the regulation of neurotrophin signaling.

In addition to its role in cellular signaling pathways, MATR3 is also involved in the regulation of cellular metabolism. It has been shown to play a role in the regulation of cellular energy metabolism, including the production of reactive oxygen species (ROS) and the production of ATP from ADP.

MATR3 is also involved in the regulation of cellular homeostasis. It has been shown to play a role in the regulation of ion homeostasis, including the regulation of sodium and potassium levels in the cells.

In conclusion, MATR3 is a protein that is involved in a wide range of cellular processes, including the regulation of mitochondrial function, stress responses, signaling pathways, and cellular metabolism and homeostasis. Its unique ability to interact with a wide range of molecules makes it an attractive drug target for the development of new therapies. Further research is needed to fully understand the role of MATR3 in cellular processes and its potential as a drug target.

Protein Name: Matrin 3

Functions: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233)

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