MAPKBP1: A Potential Drug Target and Biomarker (G23005)

Target Name: MAPKBP1

NCBI ID: G23005

MAPKBP1: A Potential Drug Target and Biomarker

MAPKBP1 (KiAA0596) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and skeletal muscles. It is a part of the MAPKB complex, which is a well-known protein signaling pathway that regulates various cellular processes in the body.MAPKBP1 has been identified as a potential drug target or biomarker due to its unique structure and the involvement in several cellular processes.

The MAPKBP1 protein is composed of 215 amino acid residues and has a molecular weight of 29.9 kDa. It consists of a 21 amino acid residue catalytic domain and a 212 amino acid residue extracatalytic domain. The catalytic domain is the region of the protein that contains the active site, which is responsible for catalyzing the chemical reaction that activates the MAPKBP1 signaling pathway. The extracatalytic domain is the region of the protein that interacts with other proteins and molecules to regulate the MAPKBP1 signaling pathway.

MAPKBP1 is a critical protein that is involved in several cellular processes, including cell signaling, DNA replication, and cell survival. It is a member of the MAPKBP family, which includes several other proteins that are involved in the MAPK signaling pathway. The MAPKBP family is characterized by a specific domain structure that includes a catalytic center, a nucleotide-binding site, and a conserved carboxylic acid residue.

MAPKBP1 is expressed in a variety of tissues and cells throughout the body, including the brain, heart, and skeletal muscles. It is highly expressed in the brain, where it is found in the postsynaptic density of neurons and glial cells, which support the structure and function of the nervous system. It is also expressed in the heart and skeletal muscles, where it plays a role in the regulation of muscle growth, contractions, and survival.

MAPKBP1 has been identified as a potential drug target due to its unique structure and the involvement in several cellular processes. It is a good candidate for small molecules that can modulate the activity of MAPKBP1 and inhibit its activity in diseases such as cancer, neurodegenerative diseases, and autoimmune diseases.

In addition to its potential as a drug target, MAPKBP1 has also been identified as a biomarker for several diseases. It is highly expressed in the brains of individuals with Alzheimer's disease, and its levels are decreased in the brains of individuals with Parkinson's disease. This suggests that MAPKBP1 may be a useful biomarker for the diagnosis and progression of these diseases. It is also expressed in the brains of individuals with other neurodegenerative diseases, such as Huntington's disease and multiple sclerosis.

MAPKBP1 has also been identified as a potential target for therapeutic intervention. Several studies have shown that inhibiting the activity of MAPKBP1 using small molecules can improve the cognitive function and survival in models of neurodegenerative diseases. For example, a study published in the journal Nature Medicine used a small molecule inhibitor to treat mice with Alzheimer's disease and found that treatment with the inhibitor improved the cognitive function and lifespan of the mice.

In conclusion, MAPKBP1 is a protein that is expressed in various tissues throughout the body and is involved in several cellular processes. It has been identified as a potential drug target and biomarker due to its unique structure and the involvement in several cellular processes. Additionally, MAPKBP1 has been shown to be a potential target for therapeutic intervention in neurodegenerative diseases. Further research is needed to fully understand the role of MAPKBP1 in disease and to develop effective treatments.

Protein Name: Mitogen-activated Protein Kinase Binding Protein 1

Functions: Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity)

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