MARK3: A Potential Drug Target for Neurodegenerative Diseases and Tumors

Target Name: MARK3

NCBI ID: G4140

MARK3: A Potential Drug Target for Neurodegenerative Diseases and Tumors

MARK3, also known as MAP/microtubule affinity-regulating kinase 3 (ISOFORM C), is a protein that plays a crucial role in the regulation of microtubules, which are dynamic cytoskeletal structures that play a central role in the mechanical properties of cells. MARK3 It is a member of the Mark family of proteins, which belongs to the cytoskeleton-related proteins and is closely related to the survival and apoptosis of neurons, cell cycle, cell division, synaptic transmission of neurons and other processes.

In recent years, researchers have conducted in-depth studies on the functions of MARK3. The results show that MARK3 plays an important role in neuron survival and apoptosis, cell cycle, cell division, synaptic transmission of neurons and other processes. In addition, MARK3 is also closely related to tumor occurrence and development. Therefore, MARK3 has become a subject of much attention and a potential drug target.

Currently, researchers are exploring drug intervention targeting MARK3 to treat various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and depression. In addition, the researchers also found that by regulating the activity of MARK3, the efficiency of neuronal synaptic transmission can be improved, which may help treat neurodegenerative diseases.

In addition to its applications in the nervous system, MARK3 also plays an important role in tumor initiation and progression. Studies have shown that MARK3 is expressed at high levels in a variety of cancers, and its expression level is positively correlated with tumor invasion and metastasis. Therefore, intervention targeting MARK3 may help treat tumors.

Overall, MARK3 is a protein with broad application prospects. Further research on the function and mechanism of MARK3 can provide new ideas and targets for the development of drugs to treat various neurodegenerative diseases and tumors.

Protein Name: Microtubule Affinity Regulating Kinase 3

Functions: Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695)

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