MARCO: A Scavenger Receptor Protein Involved in Cell Signaling and Inflammation

Target Name: MARCO

NCBI ID: G8685

MARCO: A Scavenger Receptor Protein Involved in Cell Signaling and Inflammation

MARCO, or scavenger receptor class A member 2, is a protein that is expressed in various tissues throughout the body. It is a member of the scavenger receptor family, which is a superfamily of transmembrane proteins that play a crucial role in cell signaling. MARCO is known for its ability to interact with a wide range of ligands, including small molecules, peptides, and proteins.

One of the key functions of MARCO is its role in cell signaling. It is involved in a variety of signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway. MARCO has been shown to play a critical role in the regulation of cell proliferation, differentiation, and survival.

MARCO has also been shown to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function, and has been shown to interact with a variety of cytokines and chemokines.

MARCO has also been shown to be involved in the regulation of pain. It has been shown to play a role in the regulation of pain perception and pain processing.

MARCO has also been shown to be involved in the regulation of motor behavior. It has been shown to play a role in the regulation of motor neuron function, and has been shown to interact with a variety of neurotransmitters.

MARCO has also been shown to be involved in the regulation of sensory perception. It has been shown to play a role in the regulation of sensory neuron function, and has been shown to interact with a variety of sensory cues.

Despite the many functions of MARCO, much work remains to be done in order to fully understand its role in cell signaling. Many potential drug targets have been identified, and further research is needed to determine the full range of functions of MARCO.

In conclusion, MARCO is a protein that is involved in a variety of cell signaling pathways. It has been shown to play a critical role in the regulation of cell proliferation, differentiation, and survival, as well as in the regulation of inflammation, pain, motor behavior, and sensory perception. Further research is needed to fully understand its role in cell signaling and to identify potential drug targets.

Protein Name: Macrophage Receptor With Collagenous Structure

Functions: Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263)

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