MAP2K7: Key Regulator of Cellular Signaling Pathways (G5609)

Target Name: MAP2K7

NCBI ID: G5609

MAP2K7: Key Regulator of Cellular Signaling Pathways

MAP2K7 (JNKK 2) is a protein that plays a crucial role in cellular signaling pathways. It is a key regulator of the Jun-Dam signaling pathway, which is involved in various cellular processes such as cell growth, differentiation, and survival. Despite its importance, MAP2K7 has also been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Jun-Dam signaling pathway is a complex intracellular signaling pathway that is activated by the binding of the transcription factor PDGF-JNK. The pathway involves the recruitment of various transcription factors, including AP-1, NF-kappa-B, and p53, which then induce the expression of various genes involved in cellular signaling pathways. MAP2K7 is one of the transcription factors that is recruited by the PDGF-JNK complex to regulate the expression of target genes.

MAP2K7 is a 21-kDa protein that is composed of a 191-amino acid protein core and a 20-amino acid N-terminal region. It has a key role in the regulation of cellular processes such as cell growth, differentiation, and survival. MAP2K7 has been shown to play a crucial role in the regulation of cell cycle progression, and it has been shown to interact with various cellular signaling pathways, including the PDGF-JNK pathway.

MAP2K7 has also been shown to be involved in the regulation of cellular apoptosis. Research has shown that MAP2K7 has been shown to play a role in the regulation of apoptosis, which is a critical mechanism of cellular signaling and regulation. MAP2K7 has been shown to interact with the protein Bcl-2, which is a transcription factor that is involved in the regulation of apoptosis. Together, these factors have been shown to play a role in the regulation of cellular apoptosis.

MAP2K7 has also been shown to be involved in the regulation of cellular signaling pathways that are involved in diseases such as cancer and neurodegenerative diseases. For example, studies have shown that MAP2K7 is involved in the regulation of the Wnt signaling pathway, which is involved in the development and progression of cancer. Additionally, MAP2K7 has been shown to play a role in the regulation of the neurotrophic factor (NTF) signaling pathway, which is involved in the development and progression of neurodegenerative diseases.

Despite its importance in cellular signaling pathways, MAP2K7 has also been shown to be a potential drug target and biomarker for various diseases. For example, studies have shown that MAP2K7 can be targeted by small molecules such as inhibitors of the PDGF-JNK pathway. Additionally , MAP2K7 has been shown to be involved in the regulation of cellular apoptosis, which is a potential biomarker for neurodegenerative diseases.

In conclusion, MAP2K7 is a protein that plays a crucial role in cellular signaling pathways. Its regulation of the Jun-Dam signaling pathway and its involvement in the regulation of cell cycle progression, apoptosis, and cellular signaling pathways make it an attractive target for small molecules. Further research is needed to fully understand the role of MAP2K7 in cellular signaling pathways and its potential as a drug target and biomarker for various diseases.

Protein Name: Mitogen-activated Protein Kinase Kinase 7

Functions: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074)

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