Study on POTEKP, A Potassium-dependent Protein as A Drug Target

Target Name: POTEKP

NCBI ID: G440915

Other Name(s): POTE2delta | POTE ankyrin domain family member K, pseudogene | POTEK | ACTBL3 | ACT

Study on POTEKP, A Potassium-dependent Protein as A Drug Target

POTEKP (POTassium-dependent essential protein kinase) is a protein that is expressed in various tissues throughout the body, including muscle, heart, and brain. It plays a crucial role in the regulation of ion channels and is involved in a wide range of physiological processes, including muscle contractions, heart rate, and neurotransmitter release.

Recent studies have identified POTEKP as a potential drug target for various diseases, including heart failure, hypertension, and neurodegenerative disorders. The unique aspect of POTEKP is its dependence on potassium ions, which means that any changes in the levels of potassium in the body can have a significant impact on its function.

One of the challenges in studying POTEKP is its complex cellular localization and the difficulty in isolating it from other proteins that may share similar functions. To overcome these challenges, researchers have used a variety of techniques, such as immunoprecipitation, GFP fluorescence, and biochemical assays, to study its behavior in different cellular contexts.

In addition to its potential drug-target properties, POTEKP has also been shown to have a wide range of potential applications in drug development. Its unique mechanism of action, as well as its expression in various tissues, make it an attractive target for small molecules that can modulate its activity.

Overall, POTEKP is a promising protein for drug development as it has been shown to play a crucial role in various physiological processes and has been identified as a potential drug target for various diseases. Further research is needed to fully understand its unique mechanism of action and to develop effective small molecules that can modulate its activity.

Protein Name: POTE Ankyrin Domain Family Member K, Pseudogene

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