SEPTIN2: Role in Angiogenesis and Cell Signaling Pathways (G4735)

Target Name: SEPTIN2

NCBI ID: G4735

SEPTIN2: Role in Angiogenesis and Cell Signaling Pathways

SEPTIN2 (SEPT2) is a protein that is expressed in all human tissues and is involved in the formation of new blood vessels, as well as in the regulation of cell signaling pathways.SEPTIN2 has also been shown to play a role in the development and progression of various diseases, including cancer.

The SEPTIN2 protein is composed of four distinct subunits, which are responsible for different functions in cell signaling pathways. The first subunit, SEPTIN2-A, is a 21-kDa protein that is involved in the formation of new blood vessels. It is expressed in the endothelial cell, which is the cell that forms the lining of the blood vessels. SEPTIN2-A is thought to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed.

The second subunit, SEPTIN2-B, is a 19-kDa protein that is involved in the regulation of cell signaling pathways. It is expressed in various tissues, including the brain, heart, and pancreas. SEPTIN2-B is thought to play a role in the regulation of signaling pathways that are involved in cell growth, differentiation, and survival.

The third subunit, SEPTIN2-C, is a 14-kDa protein that is involved in the regulation of cell signaling pathways. It is expressed in various tissues, including the skin, heart, and pancreas. SEPTIN2-C is thought to play a role in the regulation of signaling pathways that are involved in cell growth, differentiation, and survival.

The fourth subunit, SEPTIN2-D, is a 6.5-kDa protein that is involved in the regulation of cell signaling pathways. It is expressed in various tissues, including the brain, heart, and pancreas. SEPTIN2-D is thought to play a role in the regulation of signaling pathways that are involved in cell growth, differentiation, and survival.

SEPTIN2 has been shown to be involved in the development and progression of various diseases, including cancer. For example, studies have shown that SEPTIN2 is involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. This may be because SEPTIN2 is involved in the production of new blood vessels, which can provide a supply of oxygen and nutrients to the developing tissue.

SEPTIN2 has also been shown to be involved in the regulation of cell signaling pathways. This may be because SEPTIN2 is involved in the production of various signaling molecules, which can transmit signals from cell to cell. SEPTIN2 is thought to play a role in the regulation of signaling pathways that are involved in cell growth, differentiation, and survival.

In conclusion, SEPTIN2 is a protein that is involved in the formation of new blood vessels and the regulation of cell signaling pathways. It has been shown to play a role in the development and progression of various diseases, including cancer. Further research is needed to fully understand the role of SEPTIN2 in these processes and to develop effective treatments.

Protein Name: Septin 2

Functions: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri

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