Target Name: NPPB
NCBI ID: G4879
Other Name(s): proBNP(79-108) | proBNP(3-108) | natriuretic peptide B | Gamma-brain natriuretic peptide | NT-proBNP | BNP(4-32) | BNP(4-27) | BNP(1-32) | BNP(1-32) | ANFB_HUMAN | BNP(1-29) | BNP(3-29) | des-SerPro-BNP | Natriuretic peptides B | NT-proBNP(1-76) | natriuretic peptide precursor B | BNP | BNP(5-29) | BNP(3-30) | BNP(5-31) | BNP(4-30) | BNP(1-30) | N-terminal pro-brain natriuretic peptide | preproBNP | proBNP | BNP(3-32) | brain type natriuretic peptide | BNP-32 | Brain natriuretic peptide 29 | BNP(4-29) | Iso-ANP | BNP(1-28) | Brain natriuretic peptide 32 | Natriuretic peptide B | NT-proBNP_(HUMAN) | BNP(2-31) | BNP(4-32) | brain natriuretic factor prohormone | Brain natriuretic peptide | natriuretic protein | Brain natriuretic factor prohormone | BNP(4-31) | gamma-brain natriuretic peptide | BNP(5-32) | NT-pro-BNP | BNP(3-32)

NPPB: A Potential Drug Target for Neurological Disorders

NPPB (pro-尾-nitropiperidone) is a drug target (or biomarker) that has been shown to have a role in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. NPPB is a small molecule that is derived from the neurotransmitter serotonin.

In the brain, serotonin is involved in the regulation of various physiological processes, including mood, appetite, and sleep. When serotonin levels are imbalanced, it can lead to the development of neurological disorders. NPPB is thought to play a role in regulating serotonin levels and is a potential drug target for these disorders.

One of the unique aspects of NPPB is its ability to cross the blood-brain barrier and its effect on serotonin receptors. The blood-brain barrier is a specialized barrier that separates the brain from the bloodstream, and it is designed to protect the brain from harmful substances. However, this barrier can also prevent the delivery of drugs to the brain. NPPB is able to cross the blood-brain barrier and interact with serotonin receptors, which are found throughout the brain.

NPPB has been shown to play a role in the development and progression of Alzheimer's disease, a degenerative brain disorder that is characterized by the progressive loss of brain cells. Studies have shown that NPPB levels are decreased in the brains of individuals with Alzheimer's disease, and that increasing NPPB levels may protect against the development of this disease.

NPPB has also been shown to be involved in the development and progression of Parkinson's disease, a motor neuron disorder that is characterized by the progressive loss of motor cells. Parkinson's disease is a degenerative brain disorder that is characterized by symptoms such as tremors, rigidity, and difficulty with movement. Studies have shown that NPPB levels are decreased in the brains of individuals with Parkinson's disease, and that increasing NPPB levels may protect against the development of this disease.

In addition to its potential role in the development of Alzheimer's and Parkinson's disease, NPPB is also thought to be involved in the regulation of other physiological processes in the brain. For example, NPPB has been shown to play a role in the regulation of pain, anxiety, and depression.

Overall, NPPB is a drug target (or biomarker) that has the potential to treat a variety of neurological disorders. Its ability to cross the blood-brain barrier and interact with serotonin receptors makes it an attractive candidate for drug development. Further research is needed to fully understand the role of NPPB in the development and progression of neurological disorders.

Protein Name: Natriuretic Peptide B

Functions: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:9458824, PubMed:1672777, PubMed:1914098, PubMed:17372040). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:9458824, PubMed:1672777, PubMed:17372040, PubMed:21098034, PubMed:17349887, PubMed:25339504). Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:9458824, PubMed:1914098). Binds the clearance receptor NPR3 (PubMed:16870210)

More Common Targets

NPPC | NPR1 | NPR2 | NPR3 | NPRL2 | NPRL3 | NPS | NPSR1 | NPSR1-AS1 | NPTN | NPTN-IT1 | NPTX1 | NPTX2 | NPTXR | NPVF | NPW | NPY | NPY1R | NPY2R | NPY4R | NPY4R2 | NPY5R | NPY6R | NQO1 | NQO2 | NR0B1 | NR0B2 | NR1D1 | NR1D2 | NR1H2 | NR1H3 | NR1H4 | NR1I2 | NR1I3 | NR2C1 | NR2C2 | NR2C2AP | NR2E1 | NR2E3 | NR2F1 | NR2F1-AS1 | NR2F2 | NR2F2-AS1 | NR2F6 | NR3C1 | NR3C2 | NR4A1 | NR4A2 | NR4A3 | NR5A1 | NR5A2 | NR6A1 | NRAD1 | NRADDP | NRAP | NRARP | NRAS | NRAV | NRBF2 | NRBF2P4 | NRBP1 | NRBP2 | NRCAM | NRDC | NRDE2 | NREP | NRF1 | NRG1 | NRG2 | NRG3 | NRG4 | NRGN | NRIP1 | NRIP2 | NRIP3 | NRIP3-DT | NRIR | NRK | NRL | NRM | NRN1 | NRN1L | NRON | NRP1 | NRP2 | NRROS | NRSN1 | NRSN2 | NRSN2-AS1 | NRTN | NRXN1 | NRXN2 | NRXN2-AS1 | NRXN3 | NSA2 | NSA2P2 | NSD1 | NSD2 | NSD3 | NSDHL