TAS2R14: A Potential Drug Target and Biomarker for Taste Recognition

Target Name: TAS2R14

NCBI ID: G50840

TAS2R14: A Potential Drug Target and Biomarker for Taste Recognition

Taste is an essential sense that plays a crucial role in our daily lives. It not only helps us identify the taste and texture of food but also plays a significant role in our overall health and well-being. The TAS2R14 receptor, a member of the Taste 2 receptor family, is responsible for taste perception in the tongue. Hence, any drugs that can modulate the activity of TAS2R14 receptor could potentially be useful in treating various taste-related disorders and diseases. In this article, we will explore TAS2R14 as a drug target and biomarker for taste recognition.

TAS2R14 Receptor: Structure and Function

The TAS2R14 receptor is a G protein-coupled receptor (GPCR) that is expressed in the taste buds of the tongue. It is one of the five taste receptors, along with the TAS2R13, TAS2R15, TAS2R16, TAS2R17, and TAS2R18 receptors, that are known to play a crucial role in taste perception. The TAS2R14 receptor is also known as TRPV2, and its main function is to detect sweet, sour, and bitter tastes.

The TAS2R14 receptor is composed of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain is responsible for the receptor's interaction with the taste molecules, while the transmembrane region is responsible for the receptor's internal structure and functions as a channel. The intracellular domain is responsible for the receptor's interaction with the G protein-coupled receptor (GPCR) signaling pathway, which is a well-established mechanism for GPCR signaling.

TAS2R14 Receptor Activation

TAS2R14 receptor activation occurs in response to the presence of taste molecules, such as sweet, sour, and bitter tastes. The taste molecules bind to the receptor, causing a conformational change that results in the activation of the intracellular signaling pathway. This signaling pathway involves the interaction of the TAS2R14 receptor with the GPCR signaling pathway, leading to the production of various signaling molecules, such as IP3, Ca2+, and cAMP.

TAS2R14 Receptor Interaction with GPCR Signaling

The TAS2R14 receptor is a GPCR, which is a family of transmembrane proteins that play a crucial role in cellular signaling. GPCR signaling involves the interaction of the receptor with a GPCR-associated protein (GIPC), which is a protein that can modulate the activity of the receptor. The interaction between TAS2R14 and GIPC is a critical step in the taste perception pathway, as it allows the TAS2R14 receptor to detect taste molecules and initiate the signaling pathway.

TAS2R14 Receptor Modulation by Drugs

Drugs that can modulate the activity of TAS2R14 receptor can potentially be useful in treating various taste-related disorders and diseases. One of the most well-known drugs that can modulate TAS2R14 receptor function is the neuroprotective drug, baclofen, which is an inhibitor of GABA receptors. Baclofen has been shown to protect taste neurons from oxidative stress, which is a common complication in neuroprotective drugs.

Another drug that has been shown to modulate TAS2R14 receptor function is the anti-inflammatory drug, curcumin, which is an inhibitor of nuclear factor kappa B (NF

Protein Name: Taste 2 Receptor Member 14

Functions: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)

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