Potential Drug Target Or Biomarker: SLC45A2 (G51151)

Target Name: SLC45A2

NCBI ID: G51151

Potential Drug Target Or Biomarker: SLC45A2

SLC45A2 is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a member of the Solute Carrier Family 45 and has been identified as a potential drug target or biomarker.

SLC45A2 is a transmembrane protein that is expressed in the cell membrane of various cell types. It has a calculated molecular weight of 45 kDa and a calculated pI of 8.0. SLC45A2 is a monomer and has one splice variant, which is Transcript Variant 3.

SLC45A2 is involved in various physiological processes in the body, including the regulation of ion and water transport. It is a critical protein for maintaining the proper functioning of various organs and tissues, including the brain and the kidneys.

SLC45A2 has been identified as a potential drug target due to its involvement in the regulation of ion and water transport. The disruption of SLC45A2 has been linked to a variety of diseases, including neurodegenerative disorders, renal disease, and cardiovascular disease.

In addition to its involvement in ion and water transport, SLC45A2 is also involved in the regulation of cell signaling pathways. It has been shown to be involved in the regulation of various signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway.

SLC45A2 has also been shown to play a role in the regulation of cellular mechanics. It is involved in the regulation of cellpadding, which is the process by which cells expand and contract in response to changes in cellular volume.

In conclusion, SLC45A2 is a protein that is involved in various physiological processes in the body, including the regulation of ion and water transport, cell signaling pathways, and cellular mechanics. Its involvement in these processes makes it a potential drug target or biomarker. Further research is needed to fully understand the role of SLC45A2 in the regulation of various physiological processes and to develop effective treatments for the disorders associated with its disruption.

Protein Name: Solute Carrier Family 45 Member 2

Functions: Proton-associated glucose and sucrose transporter (By similarity). May be able to transport also fructose (By similarity). Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis (PubMed:32966160, PubMed:35469906). Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR (PubMed:32966160, PubMed:35469906)

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