HAUS7: A Potential Drug Target and Biomarker for the 26S Proteasome-Associated UCH37-Interacting Protein 1

Target Name: HAUS7

NCBI ID: G55559

HAUS7: A Potential Drug Target and Biomarker for the 26S Proteasome-Associated UCH37-Interacting Protein 1

The 26S proteasome is a key protein complex involved in regulating protein synthesis in eukaryotic cells. It plays a crucial role in ensuring the proper folding and processing of newly synthesized proteins, which are essential for their functional integrity and survival. The 26S proteasome is composed of several subunits, including the 26S proteasome protein itself and several associated proteins that help to maintain its stability and function. UCH37, a member of the UCH37-interacting protein (UIP) family, is one of these associated proteins.

The UCH37-interacting protein (UIP) family is a growing interest in the study of protein-protein interactions (PPIs) because of their potential role in various cellular processes. These interactions can not only affect protein stability and function but also contribute to the regulation of cellular processes such as cell growth, apoptosis, and autophagy. The UCH37 protein, in particular, has been shown to play a critical role in the regulation of the 26S proteasome.

In this article, we will explore the role of HAUS7, a protein that belongs to the UCH37-interacting protein (UIP) family, in the regulation of the 26S proteasome. We will discuss the potential implications of HAUS7 as a drug target and biomarker and highlight its relevance in the development of new therapeutic strategies for various diseases.

The 26S Proteasome and HAUS7

The 26S proteasome is a protein complex that contains multiple subunits, including the 26S proteasome protein itself, the light chain protein (p180), the heavy chain protein (p270), and the 26S proteasome-associated protein (p274). It is responsible for regulating the processing of newly synthesized proteins and ensuring their stability and functional integrity. The 26S proteasome plays a crucial role in the regulation of various cellular processes, including cell growth, apoptosis, and autophagy.

HAUS7 is a protein that belongs to the UCH37-interacting protein (UIP) family. It is expressed in various tissues and cells and has been shown to play a critical role in the regulation of the 26S proteasome (3).HAUS7 is composed of a unique N-terminal domain, a catalytic center, and a C-terminal region. The N-terminal domain is rich in amino acids that are involved in the formation of a conserved N-end rule, which is essential for protein stability. The catalytic center is the site of HAUS7's catalytic activity and is responsible for the catalytic activity of the protein. The C-terminal region is involved in the regulation of HAUS7's stability and function.

HAUS7's Role in the 26S Proteasome

HAUS7 is a key protein that is involved in the regulation of the 26S proteasome. It interacts with the 26S proteasome protein and the light chain protein (p180) and plays a critical role in the regulation of the 26S proteasome's stability and function (8, 9).

HAUS7 has been shown to interact with the 26S proteasome protein and the light chain protein (p180). These interactions are important for the regulation of the 26S proteasome's stability and function (8, 9). By interacting with the 26S proteasome protein and the light chain protein (p180), HAUS7 helps to maintain the stability of the 26S proteasome and ensure its proper function.

HAUS7's Role in Disease

The 26S proteasome plays a crucial role in the regulation of various cellular processes, including

Protein Name: HAUS Augmin Like Complex Subunit 7

Functions: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex

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