MREG: A Potential Drug Target for Melanoma and Cancer (G55686)

Target Name: MREG

NCBI ID: G55686

MREG: A Potential Drug Target for Melanoma and Cancer

MREG (Melanoma-associated gene 1) is a gene that has been identified as a potential drug target or biomarker for melanoma, a type of skin cancer that is the most common type of cancer in the United States. MREG is a gene that encodes a protein known as MREG, which is a transcription factor that has been shown to play a role in the development and progression of melanoma.

Recent studies have suggested that MREG may be a useful target for cancer treatment. By inhibiting the activity of MREG, researchers have found that they can reduce the growth and spread of melanoma tumors. Additionally, studies have shown that MREG may be a useful biomarker for the diagnosis and prognosis of melanoma.

One of the reasons why MREG has been identified as a potential drug target is because it is a gene that has been shown to be expressed in a wide range of tissues and cells, including cancer cells, immune cells, and normal skin cells. This makes it a promising candidate for use as a drug target or biomarker.

Another reason why MREG has been identified as a potential drug target is because it is involved in the development and progression of many types of cancer, including melanoma. Studies have shown that MREG plays a role in the development and progression of many types of cancer, including melanoma, by regulating the activity of other genes.

In addition to its potential use as a drug target or biomarker, MREG is also of interest to researchers because of its location on the genome. MREG is located on chromosome 6p21. This makes it a potential candidate for use as a cancer-specific gene therapy target.

Overall, MREG is a gene that has the potential to be a drug target or biomarker for melanoma and other types of cancer. Further research is needed to fully understand its role and potential as a therapeutic target.

Protein Name: Melanoregulin

Functions: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity)

More Common Targets