Regulation of Neuronal Excitability and Synaptic Plasticity By PTPN4

Target Name: PTPN4

NCBI ID: G5775

Regulation of Neuronal Excitability and Synaptic Plasticity By PTPN4

PTPN4 (poly (thiomarginal) phosphate neurotransmitter) is a protein that is expressed in the central nervous system (CNS) and is involved in the regulation of neuronal excitability. It is a key player in the intracellular signaling pathway known as the TGF-β pathway, which is involved in the development, maintenance, and regulation of neural circuits.

The TGF-β pathway is a well-established mechanism for the development and maintenance of neural circuits, and is involved in the regulation of a wide range of physiological processes, including neuronal excitability and synaptic plasticity. The PTPN4 protein is a key regulator of this pathway, and is involved in the regulation of neuronal excitability and synaptic plasticity.

Studies have shown that PTPN4 plays a critical role in the regulation of neuronal excitability and synaptic plasticity. PTPN4 is involved in the regulation of action potential (AP) generation and propagation, as well as the regulation of neurotransmitter release and synaptic plasticity.

In addition to its role in the regulation of neuronal excitability and synaptic plasticity, PTPN4 is also involved in the regulation of other physiological processes, including cell survival and metabolism.

Given its involvement in the regulation of neural circuits, PTPN4 is a potential drug target for the treatment of a wide range of neurological and psychiatric disorders. Studies have shown that PTPN4 is highly expressed in the brain and that its levels are often decreased in the brains of individuals with neuropsychiatric disorders.

In addition to its potential clinical applications, PTPN4 is also a potential biomarker for the diagnosis and prognosis of neuropsychiatric disorders. Studies have shown that PTPN4 levels are often decreased in the brains of individuals with neuropsychiatric disorders, and that these levels can be increased by pharmacological intervention.

Overall, PTPN4 is a protein that is involved in the regulation of neuronal excitability and synaptic plasticity, and is a potential drug target and biomarker for the treatment of neuropsychiatric disorders. Further research is needed to fully understand the role of PTPN4 in neural circuits and the potential applications of this protein.

Protein Name: Protein Tyrosine Phosphatase Non-receptor Type 4

Functions: Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton

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