Target Name: RBBP4
NCBI ID: G5928
Other Name(s): retinoblastoma-binding protein 4 | lin-53 | retinoblastoma-binding protein p48 | CAF-I p48 | RBAP48 | RB binding protein 4, chromatin remodeling factor | Histone-binding protein RBBP4 | chromatin assembly factor 1 subunit C | Nucleosome-remodeling factor subunit RBAP48 | RB binding protein 4, chromatin remodeling factor, transcript variant 1 | RBBP4 variant 1 | MSI1 protein homolog | Chromatin assembly factor I p48 subunit | nucleosome-remodeling factor subunit RBAP48 | Retinoblastoma-binding protein 4 | chromatin assembly factor I p48 subunit | CAF-1 subunit C | Retinoblastoma binding protein 4 | Chromatin assembly factor 1 subunit C | chromatin assembly factor/CAF-1 p48 subunit | Histone-binding protein RBBP4 (isoform a) | Retinoblastoma-binding protein p48 | Chromatin assembly factor/CAF-1 p48 subunit | NURF55 | RBBP-4 | CAF-I 48 kDa subunit | RBBP4_HUMAN

RBBP4: A Promising Drug Target for Cancer and AMD

Retinoblastoma-binding protein 4 (RBBP4) is a protein that is expressed in various tissues of the body, including the retina, and has been shown to play a role in the development and progression of certain diseases. The most promising potential drug targets for RBBP4 are those that can inhibit its function and slow down or stop its activity.

One of the main health concerns associated with RBBP4 is its role in the development of retinoblastoma, a type of eye cancer that is the most common cause of blindness in children. RBBP4 has been shown to promote the growth and survival of retinoblastoma cells, which could make it a useful target for cancer treatments.

Another potential drug target for RBBP4 is its role in the development of age-related macular degeneration (AMD), a progressive eye disease that is the leading cause of blindness in the over-50s. RBBP4 has been shown to contribute to the development and progression of AMD by promoting the growth and survival of retinal cells that are responsible for maintaining visual function.

In addition to its role in cancer and AMD, RBBP4 has also been shown to be involved in the development of other diseases and disorders. For example, RBBP4 has been shown to contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's, by promoting the growth and survival of brain cells that are responsible for maintaining cognitive function.

Despite the promising potential of RBBP4 as a drug target, much more research is needed to fully understand its role in these diseases and to develop effective treatments. One approach that researchers are taking to study RBBP4 is to use techniques such as RNA interference and live cell imaging to suppress its function and see how this impacts the growth and survival of cancer and disease cells.

Another approach that researchers are taking is to identify small molecules that can inhibit RBBP4's activity. These small molecules, called inhibitors, can be tested for their effectiveness in slowing down or stopping the growth and spread of cancer cells. Researchers are also using computer simulations and other tools to predict the structure and function of RBBP4 inhibitors and to identify the most promising candidates for further testing.

While the development of effective treatments for RBBP4-related diseases is an important step in understanding its role, it is also important to consider the ethical implications of targeting this protein. As with any drug, RBBP4 may be associated with potential side effects and risks, and researchers and healthcare providers must carefully weigh these potential consequences when considering its use.

Overall, RBBP4 is a protein that has the potential to be a valuable drug target for the treatment of a range of diseases, including cancer and AMD. While more research is needed to fully understand its role and to develop effective treatments, researchers are making progress and are excited about the potential of RBBP4 as a new tool in the fight against disease.

Protein Name: RB Binding Protein 4, Chromatin Remodeling Factor

Functions: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex

More Common Targets

RBBP4P2 | RBBP4P6 | RBBP5 | RBBP6 | RBBP7 | RBBP8 | RBBP8NL | RBBP9 | RBCK1 | RBFA | RBFOX1 | RBFOX2 | RBFOX3 | RBIS | RBKS | RBL1 | RBL2 | RBM10 | RBM11 | RBM12 | RBM12B | RBM14 | RBM14-RBM4 | RBM15 | RBM15-AS1 | RBM15B | RBM17 | RBM17P1 | RBM18 | RBM19 | RBM20 | RBM22 | RBM22P1 | RBM23 | RBM24 | RBM25 | RBM26 | RBM26-AS1 | RBM27 | RBM28 | RBM3 | RBM33 | RBM34 | RBM38 | RBM39 | RBM4 | RBM41 | RBM42 | RBM43 | RBM43P1 | RBM44 | RBM45 | RBM46 | RBM47 | RBM48 | RBM48P1 | RBM4B | RBM5 | RBM5-AS1 | RBM6 | RBM7 | RBM8A | RBMS1 | RBMS1P1 | RBMS2 | RBMS2P1 | RBMS3 | RBMS3-AS3 | RBMX | RBMX2 | RBMX2P1 | RBMXL1 | RBMXL2 | RBMXL3 | RBMY1A1 | RBMY1B | RBMY1D | RBMY1F | RBMY1J | RBMY2EP | RBMY2FP | RBP1 | RBP2 | RBP3 | RBP4 | RBP5 | RBP7 | RBPJ | RBPJL | RBPJP2 | RBPMS | RBPMS-AS1 | RBPMS2 | RBSN | RBX1 | RC3H1 | RC3H2 | RCAN1 | RCAN2 | RCAN3