RPS8: A Potential Drug Target and Biomarker for Diseases (G6202)

Target Name: RPS8

NCBI ID: G6202

RPS8: A Potential Drug Target and Biomarker for Diseases

Ribosomal protein S8 (RPS8) is a protein that is expressed in almost all eukaryotic cells and is involved in protein synthesis. It plays a critical role in the regulation of gene expression and is a key factor in the translation of RNA into protein. RPS8 functions as a scaffold protein that helps to maintain the stability of the ribosome, and is also involved in the assembly and disassembly of the ribosome.

Recent studies have identified RPS8 as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the biology and therapeutic potential of RPS8 and its potential as a drug target.

The biology of RPS8

RPS8 is a 28kDa protein that is composed of 156 amino acid residues. It consists of a nucleotide-binding domain (NBD), a domain for protein-protein interaction (PPI), and a carboxy-terminal domain (CTD). The NBD is the region of the protein that interacts with the nucleotide. The PPI region is the region that interacts with other proteins, and the CTD is the region that interacts with the coenzyme II.

RPS8 is a component of the ribosome and plays a critical role in the regulation of gene expression. It helps to maintain the stability of the ribosome by interacting with the nucleotide-binding domain. This interaction allows RPS8 to prevent the release of the A-site tRNA molecule, which is important for protein synthesis.

In addition to its role in maintaining the stability of the ribosome, RPS8 is also involved in the assembly and disassembly of the ribosome. It interacts with the rRNA subunit and helps to regulate the release of the fMet-tRNA molecule. This interaction between RPS8 and the fMet-tRNA molecule is critical for the assembly and disassembly of the ribosome.

The therapeutic potential of RPS8

RPS8 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Studies have shown that RPS8 is overexpressed or hyperactive in many diseases and that its levels are often elevated in the affected tissue.

For example, RPS8 has been shown to be overexpressed in various types of cancer, including breast, ovarian, and prostate cancer. In addition, studies have shown that RPS8 is hyperactive in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its role in disease, RPS8 has also been shown to be a potential biomarker for disease. Studies have shown that RPS8 levels are often elevated in the affected tissue in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. has also been shown to be a potential biomarker for cancer, as its levels are often elevated in the affected tissue.

The potential therapeutic strategies for RPS8 involve targeting its NBD and PPI regions. Studies have shown that the NBD and PPI regions of RPS8 are critical for its function, and that targeting these regions can be effective in inhibiting its activity.

In addition to inhibiting RPS8's NBD and PPI regions, other therapeutic strategies for RPS8 may include modulating its expression levels or targeting its stability. For example, studies have shown that inhibiting the activity of RPS

Protein Name: Ribosomal Protein S8

Functions: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

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