SAMSN1: A Potential Drug Target and Biomarker for Various Diseases

Target Name: SAMSN1

NCBI ID: G64092

Other Name(s): Nuclear localization signals, SAM and SH3 domain containing 1 | SAMN1_HUMAN | Src homology domain 3 (SH3)-containing adapter protein SH3 lymphocyte protein 2 | SAM domain-containing protein SAMSN-1 (isoform 1) | SAM domain-containing protein SAMSN-1 (isoform 2) | SAM domain-containing protein SAMSN-1 | NASH1 | SAM domain, SH3 domain and nuclear localization signals 1, transcript variant 2 | SH3-SAM adaptor protein | Hematopoietic adapter-containing SH3 and sterile α-motif (SAM) domains 1 | SAMSN1 variant 1 | SAM and SH3 domain containing 2 | hematopoietic adapter-containing SH3 and sterile alpha-motif (SAM) domains 1 | SAM domain, SH3 domain and nuclear localization signals 1 | SAM domain, SH3 domain and nuclear localization signals 1, transcript variant 1 | SAM domain, SH3 domain and nuclear localisation signals, 1 | SLy2 | nuclear localization signals, SAM and SH3 domain containing 1 | Hematopoietic adapter-containing SH3 and sterile alpha-motif (SAM) domains 1 | SAM domain, SH3 domain and nuclear localization signals protein 1 | HACS1 | Hematopoietic adaptor containing SH3 and SAM domains 1 | hematopoietic adaptor containing SH3 and SAM domains 1 | hematopoietic adapter-containing SH3 and sterile I+/--motif (SAM) domains 1 | Nash1 | SH3D6B | SASH2 | SAMSN1 variant 2

SAMSN1: A Potential Drug Target and Biomarker for Various Diseases

SAMSN1 (Nuclear localization signals, SAM and SH3 domain containing 1) is a protein that plays a crucial role in the regulation of gene expression in various organisms, including humans. The SAMSN1 gene has been identified as a potential drug target and a biomarker for various diseases, including cancer.

The SAMSN1 protein is a member of the SAM family, which includes several similar proteins that play a central role in the regulation of gene expression. The SAM family proteins are characterized by the presence of a SH3 domain, which is a unique feature that is found in a subset of the SAM family proteins. The SH3 domain is responsible for the protein's nuclear localization and for its ability to interact with other proteins.

SAMSN1 is a 21-kDa protein that is expressed in various tissues and cells throughout the body. It is highly expressed in the brain, heart, and liver, and is also expressed in other tissues, such as the kidney and the placenta. SAMSN1 is predominantly localized to the nucleus, where it can interact with other proteins to regulate gene expression.

SAMSN1 has been shown to play a role in the regulation of cell proliferation, apoptosis, and autophagy. It has been shown to promote the growth of cancer cells and to contribute to their survival. SAMSN1 has also been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway.

SAMSN1 has also been shown to be involved in the regulation of inflammation. It has been shown to contribute to the regulation of immune cell function and to play a role in the development of autoimmune diseases.

SAMSN1 has also been shown to be involved in the regulation of cellular signaling pathways that are involved in pain perception. It has been shown to contribute to the regulation of pain signaling pathways and to play a role in the development of chronic pain disorders.

In conclusion, SAMSN1 is a protein that has been shown to play a role in the regulation of gene expression in various organisms. Its unique feature, the SH3 domain, allows it to interact with other proteins and to contribute to the regulation of various cellular processes that are important for the health and the disease. As a result, SAMSN1 is a potential drug target and a biomarker for various diseases, including cancer, pain, and autoimmune diseases. Further studies are needed to fully understand the role of SAMSN1 in the regulation of gene expression and to develop effective treatments based on its potential as a drug target.

Protein Name: SAM Domain, SH3 Domain And Nuclear Localization Signals 1

Functions: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity)

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