SLC17A1: A Potential Drug Target for Neuronal Excitability and Synaptic Plasticity

Target Name: SLC17A1

NCBI ID: G6568

SLC17A1: A Potential Drug Target for Neuronal Excitability and Synaptic Plasticity

SLC17A1 (Na+/Pi cotransporter 1) is a protein that is expressed in various tissues and cells in the body. It is a member of the family of Na+-Pi cotransporters, which are a type of transmembrane protein that plays a crucial role in the regulation of intracellular ion homeostasis. SLC17A1 is expressed in the nuclei of neurons, and has been shown to be involved in the regulation of neuronal excitability and synaptic plasticity.

SLC17A1 has also been shown to be a potential drug target in several diseases. For example, studies have shown that modulating SLC17A1 activity has the potential to treat several neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy.

One of the reasons for the potential therapeutic benefits of SLC17A1 is its involvement in the regulation of neuronal excitability and synaptic plasticity. SLC17A1 has been shown to play a role in the regulation of action potential generation and propagation in neurons, which are critical for the proper function of the nervous system.

SLC17A1 is also involved in the regulation of neurotransmitter release and synaptic plasticity, which are critical for the development and maintenance of neural circuits. By modulating these processes, SLC17A1 has been shown to play a role in the regulation of neural circuits and the proper functioning of the nervous system.

Another potential therapeutic use of SLC17A1 is its involvement in the regulation of cell death. SLC17A1 has been shown to play a role in the regulation of apoptosis, which is a natural form of cell death that is involved in the regulation of cellular aging and homeostasis.

SLC17A1 has also been shown to play a role in the regulation of cancer cell proliferation. By modulating the activity of SLC17A1, researchers have shown that they can inhibit the growth and survival of cancer cells.

In conclusion, SLC17A1 is a protein that is involved in the regulation of a wide range of cellular processes in the body. Its involvement in the regulation of neuronal excitability and synaptic plasticity, as well as its potential therapeutic benefits in several neurological disorders, make it an attractive target for research and development. Further studies are needed to fully understand the role of SLC17A1 in the regulation of cellular processes and its potential as a drug target.

Protein Name: Solute Carrier Family 17 Member 1

Functions: Important for the resorption of phosphate by the kidney (PubMed:7826357). May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:7826357). Plays a role in urate transport in the kidney (PubMed:27906618, PubMed:25252215)

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