Target Name: ZNF182
NCBI ID: G7569
Other Name(s): ZNF21 | ZNF182 variant 1 | zinc finger protein KOX14 | HHZ150 | Zinc finger protein 182 (isoform 1) | Zinc finger protein 21 | zinc finger protein 21 (KOX 14) | KOX14 | ZN182_HUMAN | Zinc finger protein 182 | Zinc finger protein 182, transcript variant 1 | zinc finger protein 182 | Zfp182 | Zinc finger protein KOX14

ZNF182: A Key Regulator of Neural Development and Function

ZNF182 (ZNF21), a protein encoded by the ZNF1 gene, is a key regulator of neural development and function. It plays a crucial role in the formation and maintenance of neural stem cells, as well as the regulation of neural cell proliferation and differentiation. ZNF182 is also involved in the regulation of cell survival and in the development of neurodegenerative diseases.

The ZNF1 gene is located on chromosome 6p21.3 and encodes a protein with 21 kDa. ZNF182 is a 21-kDa protein that consists of 182 amino acid residues. It has a distinct N-terminal and C-terminal region, which are involved in its functions. The N-terminal region has a putative N-methylation domain and is involved in the regulation of stem cell proliferation and differentiation. The C-terminal region has a unique structural domain, which is known as the ZNF182-specific domain.

ZNF182 is a critical regulator of neural development and function. It is involved in the formation and maintenance of neural stem cells, which are a vital source of cells for the development and repair of neural tissue. ZNF182 plays a crucial role in the regulation of stem cell proliferation and differentiation by controlling the expression of key genes involved in these processes.

One of the key functions of ZNF182 is its role in the regulation of neural stem cell proliferation. ZNF182 has been shown to play a negative role in the regulation of neural stem cell proliferation by controlling the expression of the genes involved in the G1 cycle and the G0/G1 cycle. These genes include CDK4, CDK6, and p21. ZNF182 has been shown to physically interact with these genes and to regulate their expression.

ZNF182 is also involved in the regulation of neural cell differentiation. It plays a crucial role in the regulation of the transition from a stem cell to a functional neural cell. ZNF182 has been shown to play a critical role in the regulation of the expression of genes involved in cell differentiation, including the genes involved in the neural stem cell-to-neuron transition.

In addition to its functions in stem cell proliferation and differentiation, ZNF182 is also involved in the regulation of cell survival. It has been shown to play a role in the regulation of cell survival by controlling the expression of genes involved in the apoptosis pathway. ZNF182 has been shown to physically interact with the genes involved in the apoptosis pathway and to regulate their expression.

The ZNF182-specific domain is a unique structural domain that is involved in the regulation of ZNF182's functions. It is characterized by a specific domain that includes a conserved amino acid sequence and a unique N-terminal region with a putative N-methylation domain. The ZNF182-specific domain is involved in the regulation of stem cell proliferation and differentiation, as well as the regulation of cell survival.

In conclusion, ZNF182 is a key regulator of neural development and function. It plays a crucial role in the formation and maintenance of neural stem cells and in the regulation of neural cell proliferation and differentiation. ZNF182 is also involved in the regulation of cell survival and in the development of neurodegenerative diseases. The ZNF182-specific domain is a unique structural domain that is involved in the regulation of ZNF182's functions. Further research is needed to fully understand the role of ZNF182 in neural development and function.

Protein Name: Zinc Finger Protein 182

Functions: May be involved in transcriptional regulation

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